Treatment of mycosis fungoides with topical nitrosourea compounds: Further studies

Current Problems in Mycosis Fungoides and Sezary Syndrome

“…Recently used topical agents in established MF include fluorinated corticosteroids (77,78), nitrogen mustard (57,76), nitrosourea compounds (79,80), and topical cutaneous sensitizers (81,82). Clinicians have long used topical corticosteroids in the treatment of premycotic eruptions, but studies have shown that fluorinated , corticosteroid creams, when applied with occlusive techniques, will cause regression of mild to moderately advanced lesions (77,78).…”

“…The nitrosoureas, another group of compounds used in systemic cancer chemo therapy, have produced encouraging results with topical application to MF plaques or to the entire body surface (79,80). The more active compounds include 1,3-bis-(2-chloroethyl)-1-nitrosourea (BeNU) and 1-(2-chloroethyl)-3-cyclohexyl-l nitrosourea (CCNU), and these have produced partial or complete regression of early to moderately infiltrated MF lesions.…”

La chimiothérapie par voie generate dans le traitement du mycosis fongoïde

“…Cela tient sans doute à sa lenteur d'évolution, à l'efficacité -du moins durant les stades initiaux de la maladie -de traitements purement dermatologiques, comme l'application cutanée d'agents chimiothérapiques [9,27,29], le «bain» d'électrons [7], et la photochimiothérapie qui combine l'administration de méthoxsalène par voie orale et de rayons UV de grande longueur d'onde [8,11,22]; cela tient surtout à sa rareté qui empêche de réunir dans un seul centre, pendant un temps relativement court, un nombre suffisant de malades.…”