Archives of Dermatology
 1970
DOI: 10.1001/archderm.102.4.428
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Treatment of long-term tinea pedis with miconazole. Double-blind clinical evaluation

J. P. Brugmans1
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Cited by 11 publications

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“…While ketoconazole is eliminated from the stratum corneum at a rate of -2 [ug/cm2/h from 1 through 8 h after drug removal, miconazole concentrations do not change. The prolonged retention of topically applied miconazole in the skin is consistent with previous observations that miconazole remains in the skin after topical application for up to 4 days (5,14). Whether the constant concentration of miconazole in human stratum corneum represents tissue binding of the drug in skin or the inability of the drug to partition from this skin layer to the deeper epidermis and dermis in human skin has not been previously investigated.…”
Section: Discussionsupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…While ketoconazole is eliminated from the stratum corneum at a rate of -2 [ug/cm2/h from 1 through 8 h after drug removal, miconazole concentrations do not change. The prolonged retention of topically applied miconazole in the skin is consistent with previous observations that miconazole remains in the skin after topical application for up to 4 days (5,14). Whether the constant concentration of miconazole in human stratum corneum represents tissue binding of the drug in skin or the inability of the drug to partition from this skin layer to the deeper epidermis and dermis in human skin has not been previously investigated.…”
Section: Discussionsupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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