Treatment of Leprosy With 'Sulfon-Cilag'

Abstract

In this short paper the results of 19 months therapy of cases of lepromatous lepros' y with ' Sulfon-Cilag, ' administered parenter ally is presented. The Drug: Sulfori-Cilag is a derivative of the parent substance, diamino diphenyl sulphone (DDS) with the structural formula, HzN <=> SOz <=> NH-C H z-COONa The sulphone-Nacetate molecule contains 75.6% of DDS. This substance is water soluble and the Ph of the injectible solution of Sulfon-Cilag is 7•3 to 7.7. The special advantage of this new sulphone derivative appears to be the utilisation of the bactericidal properties of the active sub stance under favourable conditions of toxicity. The glucose-bisul phite complex for bacteriological agents is considered unsuitable since relatively energy-rich substances like sugar, alcohol, et::: ., by promoting oxidative processes in bacterial cells m ay oppose ' the inhibitory action of the chemotherapeutic agent on the proliferative apparatus of the bacteria. On the other hand. with Sulfon-Cilag,