Treatment of lateral epicondylitis using skin-derived tenocyte-like cells

Connell, David; Datir, Abhijit; Alyas, Faisal; Curtis, Mark J.

doi:10.1136/bjsm.2008.056457

Cited by 123 publications

(132 citation statements)

References 32 publications

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“…Another study of 60 patients with patellar tendinopathy noted clinical improvement in a group treated with MSCs injections [11]. The study was supported by Ultrasound examination and revealed reduction in tendon thickness after stem cells therapy.…”

Section: Healing Of the Tendonmentioning

confidence: 57%

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Tendon — function-related structure, simple healing process and mysterious ageing

Zabrzyński¹,

Łapaj

Paczesny³

et al. 2018

Folia Morphol

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Tendons are connective tissue structures of paramount importance to human ability of locomotion. The understanding of their physiology and pathology is gaining importance as advances in regenerative medicine are being made today. So far, very few studies were conducted to extend the knowledge about pathology, healing response and management of tendon lesions.In this paper we summarize actual knowledge on structure, process of healing and ageing of the tendons. The structure of tendon is optimized for the best performance of the tissue. Despite the simplicity of the healing response, numerous studies showed, that the problems with full recovery are common and much more significant than we thought, that is why we discussed the issue of immobilization and mechanical stimulation during healing process. The phenomenon of tendons' ageing is poorly understood, although it seems to be a natural and painless process, it is completely different to degeneration in tendinopathy. Recent studies of biological treatment reported faster and optimal healing of the tendons when augmented by growth factors and stem cells. Despite advances in biology of tendons, management of their injuries is still a challenge for physicians, therefore further studies are required to improve treatment outcomes.

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Section: Healing Of the Tendonmentioning

confidence: 57%

“…Ultrasound controlled study of lateral epicondylitis on 12 patients showed positive outcomes in clinical and ultrasonographic scale [11]. Another study of 60 patients with patellar tendinopathy noted clinical improvement in a group treated with MSCs injections [11].…”

Section: Healing Of the Tendonmentioning

confidence: 99%

Tendon — function-related structure, simple healing process and mysterious ageing

Zabrzyński¹,

Łapaj

Paczesny³

et al. 2018

Folia Morphol

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“…A pilot study of 12 patients with refractory elbow epicondylitis treated with collagen producing cells derived from dermal fibroblasts showed a significant improvement in the patient-rated tennis elbow evaluation scale and ultrasound tendon appearance [88].…”

Section: Parmacology Of Mscsmentioning

confidence: 99%

Mesenchymal stem cells for the treatment of tendon disorders

Urdzíková¹,

Lesný²,

Syková³

et al. 2013

JBiSE

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“…Future developments are likely to see an increased use of growth factors, mesenchymal stem cells and other derived tenocyte-like cells for treatment of tendon and muscle injury [17,66,67].…”

Section: Other Techniquesmentioning

confidence: 99%

Radiological interventions for soft tissue injuries in sport

Campbell

Dunn²

2012

The British Journal of Radiology

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ABSTRACT. Injection therapy has played an integral role in the rehabilitation of sports injuries for many years. The athlete's primary goal is a rapid return to sporting activity. This may be achieved by a combination of either a temporary or permanent reduction in pain, and by a pharmacological or physiological effect that promotes or accelerates a healing response. A wide variety of pharmacological agents are used. However, there is often a lack of good evidence that quantifiable effects can be achieved. There are restrictions on the use of some pharmaceutical agents. This article reviews the various pharmacological agents and bioactive substrates that are available, and discusses the current evidence base of their use in common sports injuries.

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Treatment of lateral epicondylitis using skin-derived tenocyte-like cells

Cited by 123 publications

References 32 publications

Tendon — function-related structure, simple healing process and mysterious ageing

Tendon — function-related structure, simple healing process and mysterious ageing

Mesenchymal stem cells for the treatment of tendon disorders

Radiological interventions for soft tissue injuries in sport

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