Treatment of Labial Lentigos in Atopic Dermatitis With the Frequency-Doubled Q-Switched Nd:YAG Laser

Akita, Hirotaka; Matsunaga, Kayoko; Fujisawa, Yuki; Ueda, Hiroshi

doi:10.1001/archderm.136.7.936

Cited by 7 publications

(4 citation statements)

References 4 publications

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“…These symptoms are resistant to conventional treatment modalities (7). Moreover, there have been reports of cases with black spots on the lips (12), diffuse pigmentation over the whole body (13) and with pigment spots on the intestinal tract wall (14). However, the mechanisms underlying pigmentation in AD are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Increased alpha‐melanocyte‐stimulating hormone (α‐MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis

Hiramoto

Kobayashi

Ishii

et al. 2010

Experimental Dermatology

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Patients with a specific subtype of atopic dermatitis (AD) display particular patterns of pigmentation, such as ripple pattern pigmentation on the neck, pigmented macules on the lip and diffuse pigmentation. However, the mechanism underlying these patterns has not been determined. The purpose of our research is to investigate the factors influencing this type of pigmentation in AD. We observed that AD model mice (NC/Nga mice) displayed an increase in the number of 3, 4-dihydroxyphenylalanine (Dopa)-positive melanocytes in the epidermis and intestine (jejunum and colon) while in the inflammatory state. The plasma levels of alpha-melanocyte-stimulating hormone (alpha-MSH) and adrenocoticotropin (ACTH) also increased in NC/Nga mice with dermatitis. Furthermore, the expression of melanocortin receptor 5 and melanocortin receptor 1 (MC1R) increased in the skin, and melanocortin receptor 3 (MC3R) expression increased in the intestine. However, the changes in the Dopa-positive cells of conventional NC/Nga mice were not induced by treatment with either agouti (an MC1R antagonist) or agouti-related protein (an MC3R antagonist). These results indicate that the pigmentation of AD is related to increased levels of alpha-MSH, MC1R (in the skin) and MC3R (in the intestines).

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Section: Introductionmentioning

confidence: 99%

Increased alpha‐melanocyte‐stimulating hormone (α‐MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis

Hiramoto

Kobayashi

Ishii

et al. 2010

Experimental Dermatology

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“…Effective laser therapy for the treatment of lip hyperpigmentation has been performed in the past with both normal‐pulsed and Q‐switched ruby laser, and Q‐switched alexandrite at both 752 nm and 755 nm wavelength . Additionally, Q‐switched Nd:YAG at both the 1064 nm and 532 nm wavelengths has been successfully used . Of the four studies using QSFD Nd:YAG, only one treated patients with idiopathic lip hyperpigmentation while the rest treated lip hyperpigmentation associated with Laugier‐Hunziker syndrome, Peutz‐Jeghers disease, and atopic dermatitis.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10][11][12][13][14][15][16] Additionally, Q-switched Nd:YAG at both the 1064 nm and 532 nm wavelengths has been successfully used. 1,13,[16][17][18][19][20] Of the four studies using QSFD Nd:YAG, only one treated patients which is avidly absorbed by melanin in tissue. In fact, the melanin absorbs this wavelength more so than any other laser wavelength mentioned above.…”

Section: Discussionmentioning

confidence: 99%

Q‐switched double‐frequency Nd:YAG (532 nm) laser is an effective treatment for racial lip pigmentation

Alharbi

2019

J of Cosmetic Dermatology

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Summary Introduction Lip darkening is a relatively common condition, especially in the Middle East and Southeast Asia. It is well documented in the literature and generally considered to be multifactorial. The presentation can be physiologic or pathologic and caused by a variety of local or systemic factors. Case presentation A 32‐year‐old female with skin type IV presented to the clinic with concerns of darkening lips with no associated symptoms or history of disease. On examination, her lips were homogenously dark brown with the upper lip slightly darker than the lower lip.ObjectiveTo report effectivness of Q‐switched 532 nm laser for treatment of lip pigmentation.MethodTopical 2.5% lidocaine/prilocaine (EMLA) cream was applied 30 minutes prior to laser therapy. The region was treated with Q‐switched 532 nm laser (Medlite).ResultTwo weeks after laser treatment , threre was satisfying subjective and objective improvment in lip pigmnetation.ConclusionQ‐Switched 532 nm laser effectively reduces lip pigmentation after one session with minimal adverse effects and lasting results.

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“…IPL may be particularly challenging to use on dark‐skinned patients. Some devices, however, have demonstrated promising results in the dark‐skinned individuals via their incorporated cooling technology delivered through the handpiece 12 . Some of the main advantages and disadvantages of IPL use can be seen in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Intense pulsed light for the treatment of pigmented and vascular disorders and lesions: A review

Fischer

Han

Gade

et al. 2020

Dermatological Reviews

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Background: Intense pulsed light (IPL) technology has evolved since its first introduction to the market in the 1990s. The underlying mechanism, similar to that of lasers, involves selective thermal damage to specific targets. IPL uses flashlamps and bandpass filters to emit pulsed light of adjustable wavelengths, fluences, and pulse durations. These features contribute to its versatility in treating a wide range of dermatological conditions.Aims: The purpose of this review is to highlight the history, mechanisms of action, and clinical applications of IPL in treating pigmented and vascular lesions, and to present a comparison of commonly-used IPL devices available to the market.Materials and Methods: A literature search was conducted using electronic databases (Medline, Pubmed, Embase, CINAHL, EBSCO) and textbooks, in addition to the authors' clinical experience on IPL therapy, and findings are presented here.Results: Studies have demonstrated IPL to be an efficacious and safe modality for treating a variety of pigmented and vascular disorders and lesions, including postinflammatory hyperpigmentation, melasma, ephelides and solar lentigines, telangiectasias, port-wine stains, poikiloderma of Civatte, rosacea, hemangiomas, venous malformations, and is comparable to other standard therapeutic options.Literature is supportive yet limited due to small sample sizes and short follow-up periods.Discussion: The adaptability and affordability of IPL often deem it a favorable primary or adjunctive option for treating benign pigmented and vascular skin lesions. IPL technology has evolved over time and modern devices are similar in both efficacy and side effect profile.

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Treatment of Labial Lentigos in Atopic Dermatitis With the Frequency-Doubled Q-Switched Nd:YAG Laser

Cited by 7 publications

References 4 publications

Increased alpha‐melanocyte‐stimulating hormone (α‐MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis

Increased alpha‐melanocyte‐stimulating hormone (α‐MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis

Q‐switched double‐frequency Nd:YAG (532 nm) laser is an effective treatment for racial lip pigmentation

Intense pulsed light for the treatment of pigmented and vascular disorders and lesions: A review

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