Treatment of Iron Deficiency in Heart Failure

Shamsi, Aamir Firoz; Cannatà, Antonio; Piper, Susan; Bromage, Daniel I; McDonagh, Theresa A.

doi:10.1007/s11886-023-01889-4

Cited by 9 publications

(2 citation statements)

References 78 publications

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“…Our results show that the term iron metabolism disorder occurs significantly more frequently in COVID-19 articles related to heart failure than in CVD articles on the same topic. Interestingly, iron deficiency (ID) is frequently observed in patients with heart failure [61][62][63]. Furthermore, ID correlates with an increased incidence of right ventricular failure in patients with acute HF [64,65].…”

Section: Comparison With Prior Workmentioning

confidence: 99%

Cardiovascular Comorbidities in COVID-19: Comprehensive Analysis of Key Topics

Markovič,

Ternar,

Trstenjak

et al. 2024

Interact J Med Res

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Background:The interrelation between COVID-19 and various cardiovascular and metabolic disorders has been a critical area of study. There is a growing need to understand how comorbidities like cardiovascular diseases and metabolic disorders affect the risk and severity of COVID-19. Objective:The objective of this study is to systematically analyze the association between COVID-19 and cardiovascular and metabolic disorders. The focus is on comorbidity, examining the role of cardiovascular diseases such as embolism, thrombosis, hypertension, and heart failure, as well as metabolic disorders like glucose and iron metabolism disorders. Methods:Our study involved a systematic search in PubMed for literature published from 2000 to 2022. We established two databases: one for COVID-19-related articles and another for CVD-related articles, ensuring all were peer-reviewed. In terms of data analysis, statistical methods were applied to compare the frequency and relevance of MeSH terms between the two databases. This involved analyzing the differences and ratios in the usage of these terms and employing statistical tests to determine their significance in relation to key CVDs within the COVID-19 research context. Results:The study revealed that "cardiovascular diseases" and "nutritional and metabolic diseases" were highly relevant LV1 MeSH descriptors in COVID-19 comorbidity research. Detailed analysis at LV2 and LV3 levels showed "vascular disease" and "heart disease" as prominent descriptors under cardiovascular diseases. Significantly, "glucose metabolism disorders" were frequently associated with COVID-19 comorbidities such as embolism, thrombosis, and heart failure. Furthermore, iron deficiency (ID) was notably different in its occurrence between COVID-19 and CVD articles, underlining its significance in the context of COVID-19 comorbidities. Statistical analysis underscored these differences, highlighting the importance of both glucose and iron metabolism disorders in COVID-19 research.Conclusions: This work lays the foundation for future research using a knowledge-based approach to elucidate the intricate relationships between these conditions, with the aim of developing more effective healthcare strategies and interventions in the face of ongoing pandemic challenges.

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Section: Comparison With Prior Workmentioning

confidence: 99%

Cardiovascular Comorbidities in COVID-19: Comprehensive Analysis of Key Topics

Markovič,

Ternar,

Trstenjak

et al. 2024

Interact J Med Res

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“…Deficiency of this element is a common condition that impacts a significant portion of the world's populations, contributing to the global burden of disease worldwide [3]. Iron deficiency is linked to various medical, mental, and organ-related complications [4,5].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between "Geosminophilia" (Liking the Smell of Earth) and Pica in Patients With Iron Deficiency

Özbilen

2023

Cureus

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Background: Iron deficiency is a critical global health issue. One of the intriguing manifestations linked to iron deficiency is the presence of pica. The physiological relationship between the senses of smell and taste suggests that pica may be accompanied by an inclination towards the smell of earth (geosmin). The smell of geosmin is distinct and generally recognized as a pleasing scent. The objective of this study is to explore this potential association. The sign of liking the smell of earth will now be referred to as "geosminophilia", for the first time, in this study.Methods: Patients aged 18 years and above who visited the Iron Deficiency Outpatient Clinic between September 2021 and August 2022 were chosen for this cross-sectional study. The dataset excluded those with ferritin concentrations over 100 mcg/L and transferrin saturation over 45%. Demographics, presence of pica, history of geosminophilia, and laboratory findings were documented in physical and digital patient data. The descriptive statistics, chi-square test, and independent group comparison tests were performed.Results: With a mean age of 38.7±11.7 years, the study sample comprised 280 patients, of which 263 were female and 17 were male. Ninety-six patients (34.3%) had geosminophilia, while 29 patients (10.4%) had pica. The only factors that significantly distinguished the groups based on the presence of geosminophilia were gender (p=0.04) and age (p=0.02). Using the chi-square test to compare the presence of pica and geosminophilia, a statistically significant relationship was identified (p<0.001). Additionally, 72.4% of patients who presented with pica had geosminophilia. Pica was absent in 96% of patients who did not have geosminophilia. A total of 93.8% (15/16) of pica cases with geophagia subtype exhibited the presence of geosminophilia. A significant correlation (r=0.27, p<0.001) was also observed between geosminophilia and pica. Conclusion:In iron deficiency patients, geosminophilia and the presence of pica may accompany each other. Therefore, geosminophilia has the potential to be a new symptom of iron deficiency.

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