Abstract:Refractory ventricular fibrillation (VF), intractable to conventional therapy, can be converted into a stable cardiac rhythm by immediate ventricular volume unloading using a form of mechanical circulatory assist (MCA). We investigated the efficacy of MCA in a controlled animal study in which 20 pigs were subjected to intermittent occlusions (5 times) of the left descending coronary artery (5 min. occlusion + 10 min. reperfusion). 12 of the 20 animals (60%) developed 14 events of VF. 64% of VF developed during… Show more
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