Treatment of Generalized Lichen Planus With Alefacept

Biologics, an alternative therapeutic approach for oral lichen planus

“…Similarly, the dual effect on T cells of alefacept may be true to OLP, in which T-cell activation is the key of its immunopathogenesis (18). A dramatic response to alefacept therapy has been illustrated by Fivenson et al (21) in two patients with recalcitrant generalized and OLP. Moreover, in the small case series conducted by Chang et al, (22) alefacept may have conferred a modest therapeutic response in erosive LP.…”

“…A dramatic response to alefacept therapy has been illustrated by Fivenson et al. (21) in two patients with recalcitrant generalized and OLP. Moreover, in the small case series conducted by Chang et al., (22) alefacept may have conferred a modest therapeutic response in erosive LP.…”

Comparative Analysis of Sociodemographic, Clinical Features, Laboratory Findings, and Treatment Protocols in Generalized and Localized Cutaneous Lichen Planus

“…In case reports about the sites of involvement in patients with GCLP, extensive extremity and trunk involvement has been observed [ 16 , 17 ]. In our study, we found that trunk and flexural region involvement was more common in patients with GCLP than in those with LCLP.…”

Nail Lichen Planus: Successful Treatment with Etanercept

“…There is one report of a patient with refractory oral and cutaneous LP who experienced significant improvement after therapy with efalizumab [6]. Another report on the use of alefacept in two patients with LP showed a dramatic response of all skin lesions [7]. Etanercept is a fully human TNF-a receptor fusion protein that binds TNF-a with greater affinity than natural receptors.…”