Treatment of experimental rabbit liver tumours by selectively targeted hyperthermia

Jones, Stephen; Winter, J G; Gray, Bruce N.

doi:10.1080/02656730110103519

Cited by 49 publications

(20 citation statements)

References 12 publications

(7 reference statements)

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“…In another recent study by Jones et al [23], good local tumor control was achieved using the same microspheres and tumor model as used in our study. The finding that not all of the tumor tissue was necrotic in both this study and that by Jones and colleagues suggests that AEH treatment could be improved by longer treatment times and or repeated treatments, together with the addition of different treatment modalities such as radiotherapy and chemotherapy.…”

Section: Discussionmentioning

confidence: 76%

“…This same principle can be used to target liver tumors with ferromagnetic particles, and therefore high temperatures, on exposure to an alternating magnetic field. It has been reported that it is possible to effectively target liver tumors in small animal models with hyperthermia using this technique [20][21][22][23]; two of these recent studies have reported significant tumor response [21,23].…”

mentioning

confidence: 99%

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Tumor response to arterial embolization hyperthermia and direct injection hyperthermia in a rabbit liver tumor model

Moroz

Jones

Gray

2002

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 99%

Tumor response to arterial embolization hyperthermia and direct injection hyperthermia in a rabbit liver tumor model

Moroz

Jones

Gray

2002

Journal of Surgical Oncology

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“…Jones et al [27] achieved positive temperature differences between tumor and normal liver and subsequent therapeutic responses in experimental rabbit liver tumors after arterially infused ferromagnetic microspheres. Although encouraging results have been achieved in the above-mentioned preclinical studies on arterial embolization hyperthermia, only Granov and co-workers reported on clinical use [28].…”

Section: Introductionmentioning

confidence: 99%

Clinical applications of magnetic nanoparticles for hyperthermia

Thiesen¹,

Jordan

2008

International Journal of Hyperthermia

734

556

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Magnetic fluids are increasingly used for clinical applications such as drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. The latter technique that has been developed as a cancer treatment for several decades comprises the injection of magnetic nanoparticles into tumors and their subsequent heating in an alternating magnetic field. Depending on the applied temperature and the duration of heating this treatment either results in direct tumor cell killing or makes the cells more susceptible to concomitant radio-or chemotherapy. Numerous groups are working in this field worldwide, but only one approach has been tested in clinical trials so far. Here, we summarize the clinical data gained in these studies on magnetic fluid induced hyperthermia.

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“…These results demonstrate that the antitumor effectiveness of magnetohyperthermia treatment can be associated with cell death in the target tissue and is consistent with the tumor regression observed in hamsters treated with this magnetic fluid composition and AMF. The treatment of tumors via magnetic heating has already demonstrated promising results in other tumors [16,[46][47][48][49].…”

Section: Discussionmentioning

confidence: 99%

High Efficacy in Hyperthermia-associated with Polyphosphate Magnetic Nanoparticles for Oral Cancer Treatment

Taboga¹

2014

J Nanomed Nanotechnol

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Nanotherapy applied to cancer treatment is constantly evolving, and new approaches to current techniques, such as magnetohyperthermia, are being implemented to solve and minimize the limitations of conventional therapeutic strategies. The purpose of this study was to investigate the action of polyphosphate-coated maghemite nanoparticles (MNPs) on oral squamous cell carcinoma. Human oral cancer cells (UM-SCC14A) were incubated with MNPs at various concentrations and subjected to cell proliferation tests (MTT), apoptosis assays and transmission electron image analysis. Viability and apoptotic events were time and dose dependent. These in vitro tests showed that at the intermediate concentration tested there is no significant toxicity, as confirmed by transmission electron microscopy. For this reason this MNPs concentration was chosen for the subsequent in vivo tests. Oral tumor induction was performed by applying the carcinogen DMBA to Syrian hamsters. Animals were then treated by magnetohyperthermia using MNPs. No signs of general clinical symptoms of toxicity or abnormal behavioral reactions were observed. However, animals treated with MNPs and exposed to the alternating magnetic field in the hyperthermia procedure exhibited a significant and time dependent cancer regression, as confirmed by histopathological analyses and immunohistochemistry. Actually, in quantitative terms of the magnetotherapy efficacy involving these polyphosphate-coated MNPs, 100% recovery (12/12) was observed in the oral cancer tumor bearing Syrian hamsters seven days after the treatment with the magnetohyperthermia procedure. Data supports the suggestion that the MNPs-mediated hyperthermia represents a promising strategy for the treatment of oral cancer.in patients with malignancies in the mouth region. Unlike many other oncology subspecialties, however, the rates of recurrence and overall survival have improved only modestly over the past decades, despite the continuous search for new therapeutic techniques [6,7]. Thus, it is expected that the identification and use of specific agents will lead to individualized treatments, which in turn will lead to significantly better results as manifested by more cures and better quality of life by decreasing toxicity [8].Over the last years, maghemite nanoparticles (MNPs) have appeared as a well-established technology and an important field of research in superparamagnetism of colloidal materials, characteristic which allows them to be guided with an external magnetic field [9]. Recently, MNPs have been investigated for therapeutic purposes such as hyperthermic treatment [10,11]. Magnetohyperthermia (MHT) represents a novel and promising therapy for cancer treatment [11,12], being capable of promoting the specific lysis of tumor cells, thereby improving patient outcomes while minimizing the subsequent toxicity effects [13]. The Citation: Candido NM, Calmon MF, Taboga SR, Bonilha JL, dos Santos MC, et al. (2014) High Efficacy in Hyperthermia-associated with Polyphosphate

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Treatment of experimental rabbit liver tumours by selectively targeted hyperthermia

Cited by 49 publications

References 12 publications

Tumor response to arterial embolization hyperthermia and direct injection hyperthermia in a rabbit liver tumor model

Tumor response to arterial embolization hyperthermia and direct injection hyperthermia in a rabbit liver tumor model

Clinical applications of magnetic nanoparticles for hyperthermia

High Efficacy in Hyperthermia-associated with Polyphosphate Magnetic Nanoparticles for Oral Cancer Treatment

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