Treatment of Diffuse Plane Xanthoma of the Face With the Erbium:YAG Laser

Lorenz, Susanne; Hohenleutner, Sílvía; Hohenleutner, Ulrích; Landthaler, Míchael

doi:10.1001/archderm.137.11.1413

Cited by 27 publications

(17 citation statements)

References 19 publications

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“…A predominant association of DPNX with paraproteinemia of light-chain immunoglobulins seems to occur with the λ isotype prevailing. 8,9 As in our case, an extensive cutaneous involvement is in favor of an underlying systemic disease; multiple myeloma as well as other hematological, lymph proliferative disorders were ruled out and a MGUS was considered the An Bras Dermatol. 2011;86(4Supl1):S50-2.…”

Section: Discussionmentioning

confidence: 73%

Diffuse plane xanthomatosis associated with monoclonal gammopathy

Rosmaninho

Fernandes

Guimas

et al. 2011

An. Bras. Dermatol.

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Resumo: A xantomatose plana difusa normolipêmica (XPDN) é uma dermatose adquirida rara, muitas vezes associada a doenças sistêmicas, nomeadamente neoplasias hematológicas(sobretudo o mieloma múl-tiplo) ou a processos linfoproliferativos. A XPDN pode preceder o aparecimento dessas doenças em vários anos, sendo por isso recomendada uma vigilância clínica e laboratorial periódica, mesmo para os doentes que aparentemente não apresentam uma doença associada. Descrevemos um caso associado à gamopatia monoclonal. Este caso demonstra a importância das manifestações cutâneas como primeira manifestação de doenças hematológicas importantes e por isso os clínicos devem estar familiarizados com esta entidade. Palavras-chave: Mieloma múltiplo; Paraproteinemias; Xantomatose Abstract: Diffuse plane normolipemic xanthomatosis (DPNX) is a rare, non-inherited disease that is often associated with systemic diseases, mainly malignant hematological (especially multiple myeloma) or lymph proliferative disorders. The DPNX can precede the appearance of such conditions by several years, so careful follow-up and periodic laboratory examinations are recommended even for patients that seemed to have no underlying disease. We describe a case associated with monoclonal gammopathy. This case shows that dermatological lesions can be the first manifestation of important hematological diseases and so physicians should be familiarized with this entity.

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Section: Discussionmentioning

confidence: 73%

Diffuse plane xanthomatosis associated with monoclonal gammopathy

Rosmaninho

Fernandes

Guimas

et al. 2011

An. Bras. Dermatol.

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“…Other options include chemabrasion, derm-abrasion, and ablative laser therapy. The erbium:YAG laser has been used successfully to treat facial xanthomas in one patient [14]. …”

Section: Discussionmentioning

confidence: 99%

Diffuse normolipemic plane xanthoma associated with monoclonal gammopathy

Cohen¹,

Elpern²

2015

Dermatol Pract Concept

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Diffuse normolipemic plane xanthoma (DNPX) was first described by Altman and Winkelmann in 1962. It is a rare and non-inherited form of xanthomatosis. Clinically, the dermatosis is characterized by the presence of symmetric yellowish-orange plaques that favor the neck, upper trunk, flexural folds and periorbital region. It has been recognized to be associated with hematological diseases, especially with multiple myeloma and monoclonal gammopathy. We present a patient with diffuse plane xanthoma, normal lipid level, and monoclonal gammopathy.

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“…Since Lynch and Winkelmann [2] had recognized the relationship of DPNX to diseases of the reticuloendothelial system in 1966, DPNX has frequently been attributed to underlying hematological diseases, particularly multiple myeloma and monoclonal gammopathy of undetermined significance [3] . A review of the literature revealed a predominant association of DPNX with paraproteinemia of light-chain immunoglobulins with the isotype prevailing [4,5] . Other disorders suspected to underlie DPNX include leukemia, malignant lymphoma including mycosis fungoides and Sézary syndrome, Castleman's disease and cryoglobulinemia.…”

Section: Discussionmentioning

confidence: 99%

“…Ablation by scanned continuous-wave carbon dioxide or erbium:YAG lasers is considered as a safe and effective treatment option [5] . Our patient did not feel unwell with her skin lesions and did not desire therapy.…”

Section: Discussionmentioning

confidence: 99%