Treatment of complex disease of the thoracic aorta: the frozen elephant trunk technique with the E-vita open prosthesis☆

Bartolomeo, Roberto Di; Marco, Luca Di; Armaro, Alessandro; Marsilli, D.; Leone, Alessandro; Pilato, Emanuele; Pacini, Davide

doi:10.1016/j.ejcts.2008.12.010

Cited by 88 publications

(53 citation statements)

References 23 publications

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“…20 The main cause of acute spinal cord dysfunction is believed to be the result of spinal cord ischemia from hypoperfusion during aortic cross-clamping. 8 In spite of the extensive efforts to understand the pathophysiological mechanisms following spinal cord ischemia-reperfusion, no clinical neuroprotective treatment is currently available. 13 After spinal cord ischemia-reperfusion was performed, several mechanisms emerged, including the initiation of acute oxidative stress and the release of many immune mediators such as interleukins and chemotactic factors.…”

Section: Discussionmentioning

confidence: 99%

Effects of curcumin on acute spinal cord ischemia-reperfusion injury in rabbits

Kurt

Yıldırım²,

Cemil

et al. 2014

SPI

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Object. The object of this study was to conduct a prospective, randomized, laboratory investigation of the neuroprotective effects of curcumin functionally, biochemically, and histologically in an experimental acute spinal cord ischemia-reperfusion injury on rabbits.Methods. Eighteen rabbits were randomly assigned to 1 of 3 groups: the sham group, the ischemia-reperfusion group, or the curcumin group. Spinal cord ischemia was induced by applying an infrarenal aortic cross-clamp for 30 minutes. At 48 hours after ischemia, neurological function was evaluated with modified Tarlov criteria. Biochemical changes in the spinal cord and plasma were observed by measuring levels of malondialdehyde (MDA), advanced oxidation protein products (AOPP), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitrite/nitrate, and tumor necrosis factor-a (TNF-a). Histological changes were examined with H & E staining. Immunohistochemical staining with antibodies against caspase-3 was performed to evaluate cell apoptosis after ischemia.Results. In the curcumin group, neurological outcome scores were statistically significantly better compared with the ischemia-reperfusion group. In the ischemia-reperfusion group, MDA, AOPP, and nitrite/nitrate levels were significantly elevated in the spinal cord tissue and the plasma by the induction of ischemia-reperfusion. The curcumin treatment significantly prevented the ischemia-reperfusion-induced elevation of nitrite/nitrate and TNF-a. In addition, the spinal cord tissue and the plasma SOD, GSH, and CAT levels were found to be preserved in the curcumin group and not statistically different from those of the sham group. Histological evaluation of the tissues also demonstrated a decrease in axonal damage, neuronal degeneration, and glial cell infiltration after curcumin administration.Conclusions. Although further studies including different dose regimens and time intervals are required, curcumin could attenuate a spinal cord ischemia-reperfusion injury in rabbits via reducing oxidative products and proinflammatory cytokines, as well as increasing activities of antioxidant enzymes and preventing apoptotic cell death. (http://thejns.org/doi/abs/10.3171/2013 keY WorDs • antioxidant • curcumin • ischemia-reperfusion injury • neuroprotection • oxidative stress • spinal cord injuryAbbreviations used in this paper: AOPP = advanced oxidation protein products; CAT = catalase; GSH = glutathione; MDA = malondialdehyde; SOD = superoxide dismutase; TBARS = thiobarbituric acid reactive substances; TNF = tumor necrosis factor.

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Section: Discussionmentioning

confidence: 99%

Effects of curcumin on acute spinal cord ischemia-reperfusion injury in rabbits

Kurt

Yıldırım²,

Cemil

et al. 2014

SPI

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“…В настоящее время отсутствуют исследования, посвященные при- менению гибридных технологий у пациентов с дисплазиями соединительной ткани. Тем не менее, обнадеживающие результаты применения гибридных техник у пациентов с расслоениями типа А без указа-ния на дисплазию [18] позволяют рассматривать дан-ный вид вмешательств как перспективный метод. В нашей группе пациентов в двух случаях применя-лось дополнительное стентирование дуги и нисходя-щей ГрАо.…”

Section: Discussionunclassified

The Condition of Distal Aorta After Proximal Reconstruction for Dissection in Marfan Syndrome

Чернявский¹,

Ляшенко²,

Сирота³

et al. 2016

Russ J Cardiol

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Marfan syndrome is a disease associated with high prevalence of aorta-related morbidity and mortality. Dissections and ruptures of thoracal aorta (ThAo) lead to decreased life duration in persons with Marfan syndrome with mediana at 30 year-old. Aim. To study the changes of distal aorta and clinical outcomes after surgical treatment for proximal aorta dissection in Marfan syndrome. Material and methods. In the SRICP, among patients operated for proximal aorta dissection, 14 were selected, who had histologically proven Marfan syndrome. They were followed-up. Results. In the long-term follow-up after the intervention on thoracoabdominal aorta (TAAo) was required in 2 patients. Reasons for transforming of the distal aorta were the age of the disease onset (p=0,04), acute stage of dissection (p=0,02). Changes in TAAo developed during first months after primary intervention, as in several years. Conclusion.Surgery for proximal dissections in Marfan syndrome patients is related to acceptable levels of morbidity and mortality in early and post-operation periods. Regular follow-up is required of such patients in post-operation period for on-time diagnostics and performing of secondary interventions.Russ J Cardiol 2016, 11 (139): 7-11 http://dx

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“…При проксимальном расслоении ги-бридные вмешательства, включающие протезирование восходя-щего отдела и дуги аорты с одномоментным эндопротезировани-ем нисходящей грудной аорты, зарекомендовали себя как мето-дики, не повышающие периоперационные риски и демонстриру-ющие лучшие результаты в ранние и отдаленные сроки по срав-нению с таковыми после классических открытых операций [1,2,9,12].…”

Section: хирургия 5 2015unclassified

Hybrid approach in distal aortic dissection surgery

et al. 2015

Khir. Z. im. N.I. Pirogova

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Treatment of complex disease of the thoracic aorta: the frozen elephant trunk technique with the E-vita open prosthesis☆

Cited by 88 publications

References 23 publications

Effects of curcumin on acute spinal cord ischemia-reperfusion injury in rabbits

Effects of curcumin on acute spinal cord ischemia-reperfusion injury in rabbits

The Condition of Distal Aorta After Proximal Reconstruction for Dissection in Marfan Syndrome

Hybrid approach in distal aortic dissection surgery

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