Treatment of Chemotherapy-Induced Oral Mucositis with Light-Emitting Diode

Corti, L.; Chiarion-Sileni, Vanna; Aversa, Savina; Ponzoni, A; D'Arcais, R.Flores; Pagnutti, Stefano; Fiore, Davide; Sotti, Guido

doi:10.1089/pho.2006.24.207

Cited by 53 publications

(41 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Light has also been applied combined with a photosensitizing agent in the photodynamic therapy for the treatment of neoplasias [4]. In dentistry, several studies have been directed to investigate the effects of LED light irradiation on oral mucositis [5,6], dentin hypersensitivity [7], candidiasis [8], and decontamination of carious cavities [9]. A LED therapy protocol established by Sacono et al [6] was effective in reducing the severity of mucositis induced by a chemotherapeutic agent associated with superficial scratching of the cheek pouch of hamsters.…”

Section: Introductionmentioning

confidence: 99%

Correlation between light transmission and permeability of human dentin

et al. 2011

View full text Add to dashboard Cite

The influence of dentin permeability on transdentinal LED light propagation should be evaluated since this kind of phototherapy may further be clinically used to stimulate the metabolism of pulp cells, improving the healing of damaged pulps. This study evaluated the influence of the dentin permeability on the transdentinal LED light (630 nm) transmission. Forty-five 0.5-mm-thick dentin disks were prepared from the coronal dentin of extracted sound human molars. An initial measurement of transdentinal LED light transmission was carried out by illuminating the discs in the occlusal-to-pulpal direction onto a light power sensor to determine light attenuation. The discs were treated with EDTA for smear layer removal, subjected to analysis of hydraulic conductance, and a new measurement of transdentinal LED light transmission was taken. Spearman's correlation coefficient was used for analysis of data and showed a weak correlation between dentin permeability and light attenuation (coefficient= 0.19). This result indicates that higher or lower dentin permeability does not reflect the transdentinal propagation of LED light. Significantly greater transdentinal propagation of light was observed after treatment of dentin surface with EDTA (Wilcoxon test, p<0.05). According to the experimental conditions of this in vitro study, it may be concluded that dentin permeability does not interfere in the transdentinal LED light transmission, and that smear layer removal facilitates this propagation.

show abstract

Section: Introductionmentioning

confidence: 99%

Correlation between light transmission and permeability of human dentin

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Oral mucositis (OM) is a common complication of cytotoxic chemotherapy and radiotherapy (3). This condition affects the mucosa of the gastrointestinal tract and especially the mucosa of the oral cavity and the oropharynx.…”

Section: Introductionmentioning

confidence: 99%

Use of therapeutic laser for prevention and treatment of oral mucositis

et al. 2009

View full text Add to dashboard Cite

Oral mucositis (OM) affects patients who are submitted to hematopoietic stem cell transplantation (HSCT) due to high doses of chemotherapy and/or radiotherapy. The purpose of this investigation was to perform a comparative study of the frequency and evolution of OM among patients subjected to therapeutic laser and to the conventional therapy (use of mouthwash called "Mucositis Formula"). The patients were subjected to a myeloablative conditioning regimen before the allogeneic HSCT. Twenty-two patients were selected and divided into 2 groups: group I was irradiated with InGaAlP laser (660 nm) and GaAlAs laser (780 nm), 25 mW potency, 6.3J/ cm 2 dose, in 10-s irradiation time, followed to conventional treatment; group II was subjected only to the conventional treatment. Both World Health Organization (WHO) scale and the Oral Mucositis Assessment Scale (OMAS) were used to evaluate the results. Data were analyzed by the non-parametric Wilcoxon test, with p<0.05 considered as statistically significant. Group I presented a lower frequency of OM (p=0.02) and lower mean scores, according to WHO and OMAS scales (p<0.01 and p=0.01, respectively). In conclusion, laser reduced the frequency and severity of OM, suggesting that therapeutic laser can be used both as a new form of prevention and treatment of OM.

show abstract

“…Por ser uma técnica não invasiva, simples e atraumática, sem relatórios clínicos de toxicidade, a aplicação de luz é ideal para o tratamento de tecidos sem risco de danificar as células saudáveis [30][31][32][33][34][35][36][37][38][39][40][41][42][43] .…”

Section: Revisão Da Literatura Terapia a Laserunclassified

Efetividade profilática e terapêutica do laser de baixa intensidade na mucosite bucal em pacientes submetidos ao tratamento do câncer

Neto

Westphalen

2014

Rev. da Fac. de Odontologia, UPF

View full text Add to dashboard Cite

Objetivo: o objetivo desta revisão de literatura é apresentar os diferentes protocolos clínicos randomizados utilizando o laser de baixa intensidade no manejo da IntroduçãoOs efeitos do laser de baixa intensidade podem levar a uma aceleração no processo de cicatrização de feridas, os quais são atribuídos ao estímulo de diversos processos metabólicos 1 , mediante a conversão da energia luminosa que ele aporta, transformando, por meio de processos bioquímicos e fotofísi-cos, a luz em energia útil para a célula 2 .A conversão fotoquímica é absorvida pelos fotorreceptores celulares, onde a molécula que absorve a luz transfere essa energia para outras moléculas, resultando na ativação celular e em reações quími-cas no tecido circunvizinho. Essa energia celular disponível, envolvendo as mitocôndrias e demais estruturas celulares, provoca o fenômeno de biomodulação celular 3,4 . Apesar desses efeitos, também ocorre um aumento significativo na síntese de proteínas e DNA, modulação da produção dos fatores de crescimento 5 por macrófagos, proliferação de queratinócitos, aumento da população e de granulação de mastócitos e angiogênese 3 , apresentando melhor interação com as fibras de colágeno e enzimas específicas, estimulando a microcirculação local e auxiliando o sistema linfático [6][7][8] . Além de o laser ser bem tolerado pelos pacientes, sua irradiação produz efeitos benéficos, como propriedades anti-inflamahttp://dx

show abstract

Treatment of Chemotherapy-Induced Oral Mucositis with Light-Emitting Diode

Abstract: This pilot study shows that LED treatment is safe and capable of reducing the duration of chemotherapy-induced mucositis. This result needs to be confirmed in an adequate phase III study.

Cited by 53 publications

References 14 publications

Correlation between light transmission and permeability of human dentin

Correlation between light transmission and permeability of human dentin

Use of therapeutic laser for prevention and treatment of oral mucositis

Efetividade profilática e terapêutica do laser de baixa intensidade na mucosite bucal em pacientes submetidos ao tratamento do câncer

Contact Info

Product

Resources

About