Treatment of carbon monoxide poisoning: high-flow nasal cannula versus non-rebreather face mask

Successful treatment of carbon monoxide toxicity with high flow nasal oxygen compared to mechanical ventilation

“…The standard treatment for CO toxicity in human medicine includes oxygen supplementation and hyperbaric oxygen therapy. 1,2,[6][7][8] Oxygen supplementation increases the partial pressure of oxygen, which increases the dissociation rate of carbon monoxide from haemoglobin. 1,2,6 The rate of dissociation, also referred to as the rate of decay, is exponential for carboxyhaemoglobin, resulting in a more rapid decline in FCOHb following initial interventions compared with later interventions.…”

“…HFNO has recently been described for treating CO toxicities in human medicine. Studies show that HFNO can significantly reduce the FCOHb level within the first hour compared with traditional oxygen therapy, and the half‐life is reportedly reduced to 20–45 minutes with HFNO whereas traditional oxygen has a half‐life of 70–80 minutes 4–8 . Additionally, patients suffering from mucosal inflammation secondary to smoke inhalation likely would benefit from the superior humidification of HFNO.…”

“…Studies show that HFNO can significantly reduce the FCOHb level within the first hour compared with traditional oxygen therapy, and the half-life is reportedly reduced to 20-45 minutes with HFNO whereas traditional oxygen has a half-life of 70-80 minutes. [4][5][6][7][8] Additionally, patients suffering from mucosal inflammation secondary to smoke inhalation likely would benefit from the superior humidification of HFNO. 3,16 In this case report, one patient was placed on MV due to the severity of neurologic signs and overall respiratory distress.…”

“…[9][10][11] High flow nasal oxygen (HFNO) has been described for the treatment of CO toxicity in human medicine with a reported half-life for carboxyhaemoglobin as low as 20-45 minutes. [5][6][7][8] While HFNO is becoming more popular in veterinary hospitals, to the authors' knowledge there are no described case reports where this method is used to treat CO toxicity in veterinary medicine.…”

Therapeutic study of hyperbaric oxygen on Heme Oxygenase-1 (HO-1) in patients with acute carbon monoxide poisoning and myocardial injury

“…CO poisoning, in some cases, causes severe heart poisoning that can lead to the spread of cardiomyopathy, heart failure, and even death (2). The results of previous studies all indicate the destructive effects of CO poisoning on myocardial tissue (5)(6)(7). Meanwhile, some studies have shown that this poisoning leads to histological changes in heart tissue, such as vacuolation, heart cell fusion, and myocardial cell death (8,9).…”