Treatment of Bell's Palsy:<i>An Analysis of the Available Studies</i>

Huizing, Egbert H.; Mechelse, K.; Staal, A.

doi:10.3109/00016488109133245

Cited by 30 publications

(10 citation statements)

References 17 publications

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“…8 The earlier it is done, the less danger there will be of permanent impairment. 8,9,85 Decompression is indicated for a medically treated patient with no signs of recovery of a total paralysis, and ENoG findings showing more than 95 per cent loss of activity, and without voluntary movement potentials on EMG. 11 All agree that decompression is not the mainstay of treatment for Bell's palsy.…”

Section: Decompression Surgerymentioning

confidence: 99%

Antiviral agents convey added benefit over steroids alone in Bell's palsy; decompression should be considered in patients who are not recovering

Brennan

Martens

2015

J. Laryngol. Otol.

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Section: Decompression Surgerymentioning

confidence: 99%

Antiviral agents convey added benefit over steroids alone in Bell's palsy; decompression should be considered in patients who are not recovering

Brennan

Martens

2015

J. Laryngol. Otol.

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“…We identified 15 articles [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] to consider further in answering our clinical question. Abstracts and articles were reviewed to determine the relevance of their content.…”

Section: Selection Of Articles For Reviewmentioning

confidence: 99%

Does electrical stimulation improve motor recovery in patients with idiopathic facial (Bell) palsy?

Ohtake

Zafron²,

Poranki³

et al. 2006

Physical Therapy

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in patients with idiopathic facial (Bell) palsy? Does electrical stimulation improve motor recovery http://ptjournal.apta.org/content/86/11/1558 The online version of this article, along with updated information and services, can be found online at: Collections Neurology/Neuromuscular System: Other Evidence-Based Practice Electrotherapy in the following collection(s): This article, along with others on similar topics, appears e-Letters "Responses" in the online version of this article."Submit a response" in the right-hand menu under or click on here To submit an e-Letter on this article, click

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“…Considering that ES is predominantly applied in clinical settings for treatment of facial palsy, its efficacy has been tested in the facial nerve transection model (Gittins et al, ; Huizing et al, ; Waxman, ). Rats have been subjected to 1 hr of ES immediately following nerve cut and prior to nerve repair by end‐to‐end anastomosis (Fig.…”

Section: Introductionmentioning

confidence: 99%

“…Clinical options for the treatment of denervated muscles are limited. One possibility is ES, which despite considerable controversy has been reported to have a mildly beneficial effect (Cole et al, ; Farragher et al, ; Targan et al, ; Williams, ) or no effect (Diels, ; Gittins et al, ; Huizing et al, ; Ishikawa et al, ; Kuroki et al, ; Moller and Sen, ; Mosforth and Taverner, ; Waxman, ).…”

Section: Introductionmentioning

confidence: 99%

Experimental Studies on Facial Nerve Regeneration

Rink

Bendella²,

Akkın

et al. 2019

The Anatomical Record

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Insufficient recovery after injury of a peripheral motor nerve is due to (1) inappropriate pathfinding as a result of axonal regrowth to inappropriate targets, (2) excessive collateral axonal branching at the lesion site, and (3) polyinnervation of the neuromuscular junctions (NMJs). The rat facial nerve model is often used because of its simple and reliable readout to measure recovery of function (vibrissal whisking). Over the last decades scientists have concentrated their efforts to combat mostly NMJ polyinnervation, because it turned out to be very difficult to reduce collateral axonal branching and impossible to navigate thousands of axons toward the original fascicles. In the past, several groups of scientists concentrated their efforts to reduce the activity-dependent polyinnervation of NMJs by electrical stimulation of the muscles (square 0.1 msec pulses at 5 Hz). The results showed no recovery of functions and a severe reduction in the number of innervated NMJs to approximately one fifth of those observed in intact animals. More recent experiments, however, have shown that motor recovery improved significantly following mechanical stimulation of the denervated facial muscles (vibrissal and orbicularis oculi) and that restored functions could invariably be linked to reduced polyinnervation at the NMJ while the number of innervated NMJ remained the same. These results suggest that clinically feasible and effective therapies could be developed and tested in the near future.

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Treatment of Bell's Palsy:An Analysis of the Available Studies

Cited by 30 publications

References 17 publications

Antiviral agents convey added benefit over steroids alone in Bell's palsy; decompression should be considered in patients who are not recovering

Antiviral agents convey added benefit over steroids alone in Bell's palsy; decompression should be considered in patients who are not recovering

Does electrical stimulation improve motor recovery in patients with idiopathic facial (Bell) palsy?

Experimental Studies on Facial Nerve Regeneration

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