Treatment of Acute Vocal Fold Injury With Platelet-Rich Plasma

Cobden, Serap Bulut; Öztürk, Kayhan; Duman, Selçuk; Esen, Hasan; Aktan, Tahsin Murad; Avunduk, Mustafa Cihat; Elsürer, Çağdaş

doi:10.1016/j.jvoice.2015.07.012

Cited by 27 publications

(18 citation statements)

References 23 publications

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“…In 2015, Cobden et al . reported histopathological findings in 20 Wistar rats (10 each in experimental and control groups) after applying platelet-rich plasma to injured vocal folds 12 . The authors concluded that platelet-rich plasma increased EGF receptor, FGF and fibroblast growth factor receptor 1 (FGFR1) levels in the healing vocal fold and is thus beneficial for vocal fold scar healing.…”

Section: Resultsmentioning

confidence: 99%

Platelet-rich plasma in otolaryngology

et al. 2016

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Section: Resultsmentioning

confidence: 99%

Platelet-rich plasma in otolaryngology

et al. 2016

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“…In an animal study, PRP was shown to accelerate the recovery of injured rat vocal folds. The treatment was associated with less collagen, fewer fibroblasts, and a greater level of HA [45]. The results also showed that PRP treatment was associated with less infiltration of lymphocytes, higher viability, and better integration of fatty cells [45].…”

Section: Discussionmentioning

confidence: 78%

Autologous Fat Plus Platelet-Rich Plasma versus Autologous Fat Alone on Sulcus Vocalis

Tsou

Tien

Chen

et al. 2022

JCM

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Sulcus vocalis is a frequent cause of glottic insufficiency that leads to incomplete vocal fold closure during phonation. Type II sulcus vocalis is defined as a partial defect of the lamina propria (LP). Treatment with fillers, such as fat or hyaluronic acid (HA), in the vocal folds is widely used, but the duration of effect is variable. Platelet-rich plasma (PRP) can enhance the survival of autologous fat in fat grafting, and also is used to treat sulcus vocalis. This study aimed to compare the effectiveness of autologous fat graft versus fat graft plus PRP to treat type II sulcus vocalis. Thirty-four patients with a voice handicap index (VHI) ≥ 11 were randomized to two groups, which received LP injections of fat graft (n = 17) or fat graft plus PRP (n = 17). At 1 month and 6 months after injection, the VHI decreased significantly in both groups. The fat plus PRP group had better Jitter, Shimmer, and noise to harmonic ratio (NHR) in 1 month and 6 months after surgery. The fat plus PRP group resulted in lower VHI scores one month after surgery, and stroboscopy revealed sustained smaller gaps after six months. These results indicate that a combination of fat graft plus PRP is safe and effective for treating sulcus vocalis type II and associated vocal atrophy.

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“…This trial contributes to further research on PVRP-based treatment for hearing loss ( Stolle et al, 2018 ), facial nerve palsy ( Sánchez et al, 2018 ), dysphonia ( Cobden et al, 2016 ; Özgürsoy et al, 2018 ), dysphagia ( Vidovic and Delling, 2017 ), anosmia ( Yasak et al, 2018 ), soft-tissue defects ( Eryılmaz et al, 2016 ; Tambella et al, 2018 ), or laryngotracheal reconstruction ( Sahin Onder et al, 2020 ). In addition, sterile PVRP could be administered to the sterile human body areas.…”

Section: Discussionmentioning

confidence: 99%

Autologous Platelet- and Extracellular Vesicle-Rich Plasma Is an Effective Treatment Modality for Chronic Postoperative Temporal Bone Cavity Inflammation: Randomized Controlled Clinical Trial

Vozel

Božič

Jeran

et al. 2021

Front. Bioeng. Biotechnol.

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PurposeTo determine the efficacy of autologous platelet- and extracellular vesicle-rich plasma (PVRP) to treat chronic postoperative temporal bone cavity inflammation (CPTBCI) after exhausting surgical and standard conservative therapies.Materials and MethodsPatients were randomly allocated to treatment with PVRP (PVRP group) or standard conservative methods (control group) in a setting of four once-monthly checkups and subsequent follow-up. The treatment outcome was measured with the Chronic Otitis Media Questionnaire-12 (COMQ-12), CPTBCI focus surface area, and CPTBCI symptom-free time after the fourth checkup.ResultsEleven patients from each group completed the trial; 95% of patients suffered from chronically discharging mastoid cavity (the type of CPTBCI). Within four checkups, the COMQ-12 score decreased statistically significantly in the PVRP group (p < 0.001) but not in the control group (p = 0.339). The CPTBCI foci surface area decreased statistically significantly between the first and second checkups (p < 0.0005) but not between other checkups (p > 0.05) in the PVRP group. No statistically significant differences in CPTBCI foci surface area were detected between checkups in the control group (p = 0.152). Nine patients from the PVRP group and three patients from the control group were CPTBCI symptom-free at the fourth checkup. The median symptom-free time was 9.2 months (95% CI [7.4, 11.9]) in the PVRP group. Cumulatively, 49% of patients in the PVRP group remained CPTBCI symptom-free for 12.7 months after the fourth checkup.ConclusionAutologous PVRP represents a novel additional and successful treatment modality for a chronically discharging radical mastoid cavity when the surgical and standard conservative treatment methods have been exhausted.Trial Numberhttps://clinicaltrials.gov (NCT04281901).

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Treatment of Acute Vocal Fold Injury With Platelet-Rich Plasma

Cited by 27 publications

References 23 publications

Platelet-rich plasma in otolaryngology

Platelet-rich plasma in otolaryngology

Autologous Fat Plus Platelet-Rich Plasma versus Autologous Fat Alone on Sulcus Vocalis

Autologous Platelet- and Extracellular Vesicle-Rich Plasma Is an Effective Treatment Modality for Chronic Postoperative Temporal Bone Cavity Inflammation: Randomized Controlled Clinical Trial

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