Treatment of Acute Relapses in Multiple Sclerosis

Berkovich, Regina

doi:10.1016/b978-0-12-801914-6.00024-6

Cited by 15 publications

(18 citation statements)

References 119 publications

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“…In addition, plasma exchange and intravenous immunoglobulins have occasionally been used to facilitate post-relapse remission; however, consistent evidence of their effect has been lacking [161,162] . For a more detailed overview of acute therapy of MS relapses see [163] .…”

Section: Management and Prevention Of Relapsesmentioning

confidence: 99%

Multiple Sclerosis Relapses: Epidemiology, Outcomes and Management. A Systematic Review

Kalinčík

2015

Neuroepidemiology

134

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Relapses (episodic exacerbations of neurological signs or symptoms) are a defining feature of relapsing-remitting multiple sclerosis (MS), the most prevalent MS phenotype. While their diagnostic value relates predominantly to the definition of clinically definite MS, their prognostic value is determined by their relatively high associated risk of incomplete remission resulting in residual disability. The mechanisms governing a relapse incidence are unknown, but numerous modifiers of relapse risk have been described, including demographic and clinical characteristics, many of which represent opportunities for improved disease management. Also relapse phenotypes have been associated with patient and disease characteristics and an individual predisposition to certain phenotypic presentations may imply individual neuroanatomical disease patterns. While immunomodulatory therapies and corticosteroids represent the mainstay of relapse prevention and acute management, respectively, their effect has only been partial and further search for more efficient relapse therapies is warranted. Other areas of research include pathophysiology and determinants of relapse incidence, recurrence and phenotypes, including the characteristics of the relapsing and non-relapsing multiple sclerosis variants and their responsiveness to therapies.

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Section: Management and Prevention Of Relapsesmentioning

confidence: 99%

Multiple Sclerosis Relapses: Epidemiology, Outcomes and Management. A Systematic Review

Kalinčík

2015

Neuroepidemiology

134

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“…13,15 During the past two decades, however, research has identified several forms of exercise with physical, emotional, and psychological benefits to individuals with MS, including Pilates, [16][17][18][19] yoga, 10,12 aquatics, 19 endurance training, 3,20 strength and cardiorespiratory training, 21 walking, 22 aerobic exercise, 23 and resistance training. [24][25][26] Exercise is now considered to be well tolerated for individuals with MS and is commonly recommended for improved physical and emotional functioning.…”

Section: Benefits Of Exercisementioning

confidence: 99%

Therapeutic Yoga: Symptom Management for Multiple Sclerosis

Rogers

MacDonald

2015

The Journal of Alternative and Complementary Medicine

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Multiple sclerosis (MS) is the most common autoimmune inflammatory demyelinating disease of the central nervous system, affecting over 2.3 million people worldwide. According to the National Institute of Neurological Disorders and Stroke, the age of disease onset is typically between 20 and 40 years, with a higher incidence in women. Individuals with MS experience a wide range of symptoms, including declining physical, emotional, and psychological symptoms (e.g., fatigue, imbalance, spasticity, chronic pain, cognitive impairment, bladder and bowel dysfunction, visual and speech impairments, depression, sensory disturbance, and mobility impairment). To date, both the cause of and cure for MS remain unknown. In recent years, more individuals with MS have been pursuing alternative methods of treatment to manage symptoms of the disease, including mind-body therapies such as yoga, meditation, breathing, and relaxation techniques.It has been suggested that the practice of yoga may be a safe and effective way of managing symptoms of MS. Therefore, the purpose of this paper is to summarize the most relevant literature on exercise and mindbody modalities to treat MS symptoms and, more specifically, the benefits and potential role of yoga as an alternative treatment of symptom management for individuals with MS. The article also discusses future directions for research.

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“…The prevention of relapse is the main objective of multiple sclerosis management (Berkovich, 2013). This review found that the Number Needed to Treat (NNT) for prevention of one relapse is 5.…”

Section: Resultsmentioning

confidence: 99%

“…In general, treatment may include treatment of acute relapses, DMT in combination with symptomatic treatment, and complications associated with MS (Pandit and Murthy, 2011). Treatments of moderate-severe acute MS relapses include systemic corticosteroids or adrenocorticotropic hormone (ACTH) therapy (Berkovich, 2013). Symptomatic treatments include glucocorticoid therapy, benzodiazepines, muscle relaxers, anticonvulsants, antidepressants, and medications used to treat bladder and bowel dysfunction (Antezana, 2014).…”

Section: Resultsmentioning

confidence: 99%