Treatment of actinic keratoses with birch bark extract: a pilot study

Huyke, Constance; Laszczyk, Melanie N.; Scheffler, Armin; Ernst, Reinhard; Schempp, Christoph M.

doi:10.1111/j.1610-0387.2006.05906.x

Cited by 37 publications

(35 citation statements)

References 36 publications

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“…Bet is the most important compound in birch bark, which has been used in folk medicine for treatment of skin diseases [15], such as actinic keratoses and pre-carcinoma status of skin [16,17]. Important derivatives with an increased antitumor activity have been produced from Bet [15], which affects colorectal carcinoma (DLD-1), breast carcinoma (MCF7), prostate cancer (PC-3) and lung cancer (A549) [8].…”

Section: Discussionmentioning

confidence: 99%

Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models

Şoica

Dehelean

Danciu

et al. 2012

IJMS

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Given the present high incidence of melanoma and skin cancer, interest in potential drugs of plant origin has increased significantly. Pentacyclic lupane-type triterpenes are widely distributed in plants, offering numerous pharmacological benefits. Betulin is an important compound in the bark of Betula pendula Roth and has important therapeutic properties, including antitumor activities. Its biological effect is limited by its poor water solubility, which can be improved by cyclodextrin complexation. The best results have been obtained by using a novel cyclodextrin derivative, octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonate)]-γ-CD. The complexes between betulin and the previously mentioned cyclodextrin were analyzed by scanning electron microscopy (SEM)and differential scanning calorimetry (DSC) and pharmacologically evaluated in vitro (MTT and immunocytochemistry tests) and in vivo in C57BL/6J mice. The solubility of betulin is improved by cyclodextrin complexation, which creates a stable complex that improves the in vitro and in vivo properties of the active compound.

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Section: Discussionmentioning

confidence: 99%

Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models

Şoica

Dehelean

Danciu

et al. 2012

IJMS

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“…A variety of studies has investigated monotherapies or fixed combination therapies, for instance mistletoe treatment in cancer (see above) and in hepatitis, 95 – 97 betulin-based oleogel in actinic keratosis, 98 , 99 rhythmic embrocation (with Solum oil) in chronic pain, 100 hepar magnesium in seasonal fatigue symptoms, 101 arnica/echinacea in care of umbilical cords of newborns, 102 , 103 eurythmy therapy in attention deficit/hyperactivity disorder 104 , body-temperature enemas in febrile children, 105 mistletoe combined with Articulatio coxae or genus D30 in osteoarthritis of the hip and knee, 106 Gelsemium comp. in acute occipital muscular pain, 107 and many others.…”

Section: Research On Anthroposophic Medicinementioning

confidence: 99%

Anthroposophic Medicine: An Integrative Medical System Originating in Europe

Kienle

Albonico²,

Baars

et al. 2013

Glob Adv Health Med

158

198

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Anthroposophic medicine is an integrative multimodal treatment system based on a holistic understanding of man and nature and of disease and treatment. It builds on a concept of four levels of formative forces and on the model of a three-fold human constitution. Anthroposophic medicine is integrated with conventional medicine in large hospitals and medical practices. It applies medicines derived from plants, minerals, and animals; art therapy, eurythmy therapy, and rhythmical massage; counseling; psychotherapy; and specific nursing techniques such as external embrocation. Anthroposophic healthcare is provided by medical doctors, therapists, and nurses. A Health-Technology Assessment Report and its recent update identified 265 clinical studies on the efficacy and effectiveness of anthroposophic medicine. The outcomes were described as predominantly positive. These studies as well as a variety of specific safety studies found no major risk but good tolerability. Economic analyses found a favorable cost structure. Patients report high satisfaction with anthroposophic healthcare.

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“…Extracts of birch bark were tested in actinic keratosis, showing an important therapeutic activity [23]. Birch tree outer bark contains betulin as major compound, but also other pentacyclic triterpens [18].…”

Section: Resultsmentioning

confidence: 99%

Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation

Dehelean

Şoica

Ledeți

et al. 2012

Chemistry Central Journal

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BackgroundPentacyclic triterpenes, mainly betulin and betulinic acid, are valuable anticancer agents found in the bark of birch tree. This study evaluates birch bark extracts for the active principles composition.ResultsNew improved extraction methods were applied on the bark of Betula pendula in order to reach the maximum content in active principles. Extracts were analyzed by HPLC-MS, Raman, SERS and 13C NMR spectroscopy which revealed a very high yield of betulin (over 90%). Growth inhibiting effects were measured in vitro on four malignant human cell lines: A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma), HeLa (cervix adenocarcinoma) and MCF7 (breast adenocarcinoma), by means of MTT assay. All of the prepared bark extracts exerted a pronounced antiproliferative effect against human cancer cell lines. In vivo studies involved the anti-inflammatory effect of birch extracts on TPA-induced model of inflammation in mice.ConclusionsThe research revealed the efficacy of the extraction procedures as well as the antiproliferative and anti-inflammatory effects of birch extracts.

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Treatment of actinic keratoses with birch bark extract: a pilot study

Abstract: In this pilot study, a standardized birch bark extract was effective in the treatment of actinic keratoses. This therapy is easy to perform and it has no side effects. Birch bark ointment may be a new therapeutic option for actinic keratoses.

Cited by 37 publications

References 36 publications

Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models

Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models

Anthroposophic Medicine: An Integrative Medical System Originating in Europe

Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation

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