Treatment of abortions infected with clostridium welchii

Decker, Wayne H.; Hall, W.

doi:10.1016/0002-9378(66)90124-4

Cited by 45 publications

(22 citation statements)

References 10 publications

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“…Hysterectomy without surgical resection of the adnexal structures may be inadequate because of rapid C. perfringens involvement of extrauterine structures [1]. If prompt recognition and surgical treatment identify tubes and ovaries without evidence of necrosis, the conservation of the adnexal structures may not confer a poorer outcome [14]. Conservative treatment with supportive care and broad spectrum antibiotics (no surgical treatment) is less commonly performed.…”

Section: Discussionmentioning

confidence: 99%

Life-Threatening Clostridial Sepsis in a Postmenopausal Patient with Degenerating Uterine Leiomyoma

Bryant

Perry²,

Shah³

et al. 2010

Case Reports in Medicine

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Section: Discussionmentioning

confidence: 99%

Life-Threatening Clostridial Sepsis in a Postmenopausal Patient with Degenerating Uterine Leiomyoma

Bryant

Perry²,

Shah³

et al. 2010

Case Reports in Medicine

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“…perfringens gas gangrene of the pelvic organs with shock and hemolysis (not CSTS) was a common sequela of unsafe abortion prior to legalization of abortion in the United States in 1973. The fatality rate for these gas gangrene patients was approximately 70% after reaching appropriate medical care [39][40][41][42][43]. Between 1977 and 2007, published reports of gynecologic Clostridium spp.…”

Section: Csts Case Updates 2008-2011mentioning

confidence: 99%

Gynecologic Clostridial Toxic Shock in Women of Reproductive Age

Zane¹,

Guarner

2011

Curr Infect Dis Rep

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Clostridial toxic shock, caused by Clostridium sordellii or Clostridium perfringens, is a rare and largely fatal syndrome among reproductive-aged women with genital tract infection, and may occur following various pregnancy outcomes or without pregnancy. Clinicians should be aware of common clinical features of this very rapidly-progressing syndrome including abdominal pain, tachycardia, hypotension, third-space fluid accumulations, hemoconcentration, and marked leukemoid response, often with lack of fever. In this review, we summarize known cases through mid-2011 and information on clinical presentation, diagnosis, treatment, and results of recent investigations regarding pathogenesis, including germination, toxins, and host response that may have important implications for development of preventive or therapeutic interventions.

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“…Because of the rapid development, death occasionally precedes diagnosis, with a mortality rate of 50 -85%. 3 C perfringens produces potent extracellular toxins, which both initiate and mediate the local and systemic manifestation of the infection. The alphatoxin is the most potent and has phospholipase C and sphingomyelinase activities.…”

Section: Commentmentioning

confidence: 99%