Treatment of a Chronic Cutaneous Surgical Wound With Platelet-Rich Fibrin

Chiaravalloti, Anthony J.; Zubkov, Bella; Zubkov, Alexander Y.

doi:10.1097/dss.0000000000001246

Cited by 9 publications

(7 citation statements)

References 5 publications

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“…PRF has been used in the treatment of a number of other ulcers (Table 4). [5][6][7][8] A significant limitation of our study is its being a small observational case series from one centre. Much larger number of patients are required for true validation; however, the rapid healing of chronic ulcers was deemed sufficiently impressive.…”

Section: Discussionmentioning

confidence: 98%

Platelet rich fibrin: A novel treatment for trophic ulcer in Hansen's disease

et al. 2022

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Patients with Hansen's disease are liable to develop non-healing trophic ulcers. The aim of this study was to determine the efficacy of autologous platelet rich fibrin (PRF) applied at weekly intervals in the management of trophic ulcers. The mean age of the patients, duration and size of ulcer were 44.3 years, 7.4 months and 6.25cm2 respectively. After the third sessions of weekly dressing, there was a significant reduction in the ulcer area (p value = 0.015). All ulcers healed by a maximum of six weeks. No adverse events were noted. PRF thus seems a feasible, safe, simple and cost-effective treatment method.

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Section: Discussionmentioning

confidence: 98%

Platelet rich fibrin: A novel treatment for trophic ulcer in Hansen's disease

et al. 2022

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“…A FRP, considerada a segunda geração de concentrados plaquetários, possui resultados promissores em vários aspectos analisados, de tal forma que fomentam pesquisas nas mais diversas áreas, já sendo relatada sua utilização na dermatologia (Chiaravalloti et al, 2018) medicina esportiva (Ehrenfest et al, 2014) implantologia (Dohle et al, 2018) e em procedimentos estéticos (Cieslik-Bielecka et al, 2012).…”

Section: Introductionunclassified

Uso de biomateriais e rosuvastatina tópica aumenta angiogênese de feridas cirúrgicas em coelhos

Ferreira

Vicentini

Breda

et al. 2021

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Estudos têm sido realizados para verificar os efeitos de biomateriais, como o plasma rico em plaquetas (PRP) e a fibrina rica em plaquetas (FRP) e a sua contribuição para o processo de cicatrização de feridas por meio da liberação de fatores de crescimento que têm propriedades de indução de regeneração tecidual. Muitas evidências também se mostram favoráveis ao uso tópico da rosuvastatina (RSV) em lesões de pele, por modificar de forma positiva o fluxo sanguíneo basal tecidual. No entanto, não está claro se este efeito está envolvido no aumento do fluxo sanguíneo e por consequência uma melhora no processo cicatricial. Neste sentido, o presente estudo analisou a quantidade de fibroblastos e número de vasos em feridas induzidas experimentalmente em coelhos após tratamento com e sem associação dos biomateriais e RSV. A hipótese baseia-se que o uso tópico de um fármaco hipolipemiante associado a um biomaterial possa aumentar a quantidade de fibroblastos e angiogênese após lesão experimentalmente induzida, e com isso aumentando a colagenização para produção de uma cicatriz mais homogênea. Verificou-se que a associação da FRP e RSV promoveu um efeito aditivo aumentando em 135% a angiogênese. O uso da RSV isolada também proporcionou um aumento de 77% na quantidade de fibroblastos. Concluiu-se que tanto a FRP quanto a RSV possuem bons efeitos cicatrizantes, de tal forma que a associação entre elas foi benéfica e demonstrou um possível efeito aditivo.

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“…Currently, platelet concentrates have been the focus of many basic and clinical studies, [10], with the majority of scientific articles mainly addressing its therapeutic potential as a surgical adjuvant in dentistry, such as peri-implantology and maxillofacial surgery [11][12][13][14]. Besides, further studies on the treatment of chronic wounds and muscle-tendinous lesions in humans have introduced the topic in the medical field as a promising therapeutic potential [15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Methodological variations affect the release of VEGF in vitro and fibrinolysis’ time from platelet concentrates

et al. 2020

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Blood Concentrates (BCs) are autologous non-transfusional therapeutical preparations with biological properties applied in tissue regeneration. These BCs differ in the preparation method, in fibrin network architecture, growth factors release as well as in platelet/cell content. Methodological changes result in distinct matrices that can compromise their clinical effectiveness. The present study evaluated the influence of different g-forces and types of tubes in the release of vascular endothelial growth factor (VEGF) from platelet-rich fibrin (PRF) as a function of time. The PRF-like samples were obtained with three g-forces (200, 400, and 800 x g) for 10 minutes in pure glass tubes or in polystyrene-clot activator tubes. Scanning and Transmission electron microscopy was used to morphometric analyzes of PRF's specimens and flow cytometry was used to quantify VEGF slow release until 7 days. Our results showed that platelets were intact and adhered to the fibrin network, emitting pseudopods and in degranulation. The fibrin network was rough and twisted with exosomic granulations impregnated on its surface. An increase in the concentration of VEGF in the PRF supernatant was observed until 7 days for all g forces (200, 400 or 800 xg), with the highest concentrations observed with 200 x g, in both tubes, glass or plastic. Morphological analyzes showed a reduction in the diameter of the PRF fibers after 7 days. Our results showed that g-force interferes with the shape of the fibrin network in the PRF, as well as affect the release of VEGF stored into platelets. This finding may be useful in applying PRF to skin lesions, in which the rapid release of growth factors can favor the tissue repair process. Our observations point to a greater clarification on the methodological variations related to obtaining PRF matrices, as they can generate products with different characteristics and degrees of effectiveness in specific applications.

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Treatment of a Chronic Cutaneous Surgical Wound With Platelet-Rich Fibrin

Cited by 9 publications

References 5 publications

Platelet rich fibrin: A novel treatment for trophic ulcer in Hansen's disease

Platelet rich fibrin: A novel treatment for trophic ulcer in Hansen's disease

Uso de biomateriais e rosuvastatina tópica aumenta angiogênese de feridas cirúrgicas em coelhos

Methodological variations affect the release of VEGF in vitro and fibrinolysis’ time from platelet concentrates

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