Treatment for primary postpartum haemorrhage

Abstract

Analysis 1.2. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 2 Serious maternal morbidity.. .. .. . Analysis 1.3. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 3 Admission to intensive care unit.. .. . Analysis 1.4. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 4 Hysterectomy.. .. .. .. .. . Analysis 1.5. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 5 Average blood loss after enrolment in millilitres. Analysis 1.6. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 6 Blood loss 500 mL or more after enrolment. Analysis 1.7. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 7 Blood transfusion.. .. .. .. .. Analysis 1.8. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 8 Blood loss 1000 mL or more after enrolment. Analysis 1.9. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 9 Additional uterotonics.. .. .. .. Analysis 1.10. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 10 Manual removal of the placenta after enrolment. Analysis 1.11. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 11 Uterine tamponade after enrolment.. . Analysis 1.12. Comparison 1 Misoprostol (any route) versus placebo or no additional treatment given to women simultaneously treated with conventional uterotonics, Outcome 12 Artery ligation (uterine and/or hypogastric arteries

Oxytocin versus Carbetocin in the prevention of primary post-partum haemorrhage in hypertensive disorders of pregnancy

“…Nausea occurred in 4% cases and 6% occurred in abdominal pain in carbetocin group and nausea occurred in 4% cases, 2% headache and 8% occurred in abdominal pain in oxytocin group. Nausea and abdominal pain were common side-effects of carbetocin, as found in previous studies [5,11,12] . Yuen et al [13] reported carbetocin is a long-acting synthetic analogue of oxytocin with agonist properties.…”

Oxytocin versus Carbetocin in the prevention of primary post-partum haemorrhage in hypertensive disorders of pregnancy

“…Nausea occurred in 4% cases and 6% occurred in abdominal pain in carbetocin group and nausea occurred in 4% cases, 2% headache and 8% occurred in abdominal pain in oxytocin group. Nausea and abdominal pain were common side-effects of carbetocin, as found in previous studies [5,11,12] . Yuen et al [13] reported carbetocin is a long-acting synthetic analogue of oxytocin with agonist properties.…”

RETRACTED: Rectal misoprostol versus intravenous oxytocin for prevention of postpartum hemorrhage

“…Rectal misoprostol was shown to be an effective first- [16] and second-line treatment for the management of PPH unresponsive to oxytocin [14]. Our results show a comparable effect of rectal misoprostol to oxytocin intravenous infusion as prophylaxis against PPH.…”

“…Although 600 μg of oral misoprostol was unequivocally less effective than 10 IU of oxytocin intramuscularly or intravenously in the management of the third stage of labor, and had more side effects (mainly shivering and pyrexia), as reported by the largest randomized trial to date [21], the use of rectal misoprostol appears more promising. Rectal misoprostol was shown to be an effective first- [16] and second-line treatment for the management of PPH unresponsive to oxytocin [14]. Our results show a comparable effect of rectal misoprostol to oxytocin intravenous infusion as prophylaxis against PPH.…”

Maternal and Neonatal Outcomes in Pregnancies Complicated by Systemic Lupus Erythematosus: A Population-Based Study

“…The risk factors for postpartum hemorrhage include first pregnancy, obesity, macrosomia, prolonged or augmented labour, antepartum hemorrhage, placental complications, CS, over-distended uterus, multiple pregnancy, PIH, medication, trauma, and blood clotting disorders. [13][14][15] In our study, SLE, ITP, first pregnancy, higher maternal age, previous pregnancy loss, and oligohydramnios were all found to contribute to the higher rate of postpartum hemorrhage.…”

Oxytocin versus Carbetocin in the prevention of primary post-partum haemorrhage in hypertensive disorders of pregnancy

“…Nausea occurred in 4% cases and 6% occurred in abdominal pain in carbetocin group and nausea occurred in 4% cases, 2% headache and 8% occurred in abdominal pain in oxytocin group. Nausea and abdominal pain were common side-effects of carbetocin, as found in previous studies [5,11,12] . Yuen et al [13] reported carbetocin is a long-acting synthetic analogue of oxytocin with agonist properties.…”

RETRACTED: Rectal misoprostol versus intravenous oxytocin for prevention of postpartum hemorrhage

“…Rectal misoprostol was shown to be an effective first- [16] and second-line treatment for the management of PPH unresponsive to oxytocin [14]. Our results show a comparable effect of rectal misoprostol to oxytocin intravenous infusion as prophylaxis against PPH.…”

“…Although 600 μg of oral misoprostol was unequivocally less effective than 10 IU of oxytocin intramuscularly or intravenously in the management of the third stage of labor, and had more side effects (mainly shivering and pyrexia), as reported by the largest randomized trial to date [21], the use of rectal misoprostol appears more promising. Rectal misoprostol was shown to be an effective first- [16] and second-line treatment for the management of PPH unresponsive to oxytocin [14]. Our results show a comparable effect of rectal misoprostol to oxytocin intravenous infusion as prophylaxis against PPH.…”

Maternal and Neonatal Outcomes in Pregnancies Complicated by Systemic Lupus Erythematosus: A Population-Based Study

“…The risk factors for postpartum hemorrhage include first pregnancy, obesity, macrosomia, prolonged or augmented labour, antepartum hemorrhage, placental complications, CS, over-distended uterus, multiple pregnancy, PIH, medication, trauma, and blood clotting disorders. [13][14][15] In our study, SLE, ITP, first pregnancy, higher maternal age, previous pregnancy loss, and oligohydramnios were all found to contribute to the higher rate of postpartum hemorrhage.…”

Oxytocin versus Carbetocin in the prevention of primary post-partum haemorrhage in hypertensive disorders of pregnancy

“…Nausea occurred in 4% cases and 6% occurred in abdominal pain in carbetocin group and nausea occurred in 4% cases, 2% headache and 8% occurred in abdominal pain in oxytocin group. Nausea and abdominal pain were common side-effects of carbetocin, as found in previous studies [5,11,12] . Yuen et al [13] reported carbetocin is a long-acting synthetic analogue of oxytocin with agonist properties.…”

RETRACTED: Rectal misoprostol versus intravenous oxytocin for prevention of postpartum hemorrhage

“…Rectal misoprostol was shown to be an effective first- [16] and second-line treatment for the management of PPH unresponsive to oxytocin [14]. Our results show a comparable effect of rectal misoprostol to oxytocin intravenous infusion as prophylaxis against PPH.…”

“…Although 600 μg of oral misoprostol was unequivocally less effective than 10 IU of oxytocin intramuscularly or intravenously in the management of the third stage of labor, and had more side effects (mainly shivering and pyrexia), as reported by the largest randomized trial to date [21], the use of rectal misoprostol appears more promising. Rectal misoprostol was shown to be an effective first- [16] and second-line treatment for the management of PPH unresponsive to oxytocin [14]. Our results show a comparable effect of rectal misoprostol to oxytocin intravenous infusion as prophylaxis against PPH.…”

Maternal and Neonatal Outcomes in Pregnancies Complicated by Systemic Lupus Erythematosus: A Population-Based Study

“…The risk factors for postpartum hemorrhage include first pregnancy, obesity, macrosomia, prolonged or augmented labour, antepartum hemorrhage, placental complications, CS, over-distended uterus, multiple pregnancy, PIH, medication, trauma, and blood clotting disorders. [13][14][15] In our study, SLE, ITP, first pregnancy, higher maternal age, previous pregnancy loss, and oligohydramnios were all found to contribute to the higher rate of postpartum hemorrhage.…”