2013
DOI: 10.18632/aging.100617
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Abstract: Type 2 diabetes (T2D) is predicted to affect one in three Americans by the year 2050 and is a leading cause of blindness, end stage renal failure and loss of limb with associated costs exceeding $180 billion/year. Insulin resistance in liver and skeletal muscle are major factors in the pathogenesis of T2D, with a strong relationship between ectopic lipid content in liver and skeletal muscle with insulin resistance and T2D in both humans and rodent models of NAFLD and T2D (Shulman, J. Clin. Invest. 2000; 106:1… Show more

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Cited by 6 publications
(4 citation statements)
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“…26 In addition, lipid synthesis of adipose tissue is weakened while lipolysis is strengthened when IR occurs. 27 Therefore, TG and FFA play an important role in IR in NAFLD patients. The PI3K-AKT signaling pathway is one of the major pathway of IR.…”
Section: Discussionmentioning
confidence: 99%
“…26 In addition, lipid synthesis of adipose tissue is weakened while lipolysis is strengthened when IR occurs. 27 Therefore, TG and FFA play an important role in IR in NAFLD patients. The PI3K-AKT signaling pathway is one of the major pathway of IR.…”
Section: Discussionmentioning
confidence: 99%
“…12 Insulin resistance develops as a result of the reduced responsiveness of target tissues to insulin due to decreased receptor and/or downstream signaling protein activity, rather than a reduced circulating insulin level. 13,14 PI3K/Akt plays a central role in several pathway-related energy homeostases, including leptin, pro-opiomelanocortin (POMC), TNF-a, adiponectin, and cytokine stimulation. [15][16][17][18] PI3K consists of a catalytic subunit (p110) and a regulatory subunit (p85α).…”
Section: Discussionmentioning
confidence: 99%
“… 46 Noteworthy, IR and metabolic syndrome are multifactorial. 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 …”
Section: Rapamycin Prevents Obesitymentioning
confidence: 99%