volume 5, issue 11, P791-792 2013
DOI: 10.18632/aging.100617
View full text
Rachel J. Perry, Gerald I. Shulman

Abstract: Type 2 diabetes (T2D) is predicted to affect one in three Americans by the year 2050 and is a leading cause of blindness, end stage renal failure and loss of limb with associated costs exceeding $180 billion/year. Insulin resistance in liver and skeletal muscle are major factors in the pathogenesis of T2D, with a strong relationship between ectopic lipid content in liver and skeletal muscle with insulin resistance and T2D in both humans and rodent models of NAFLD and T2D (Shulman, J. Clin. Invest. 2000; 106:…

expand abstract