Traumatic neuromas of the penis: a clinical, histopathological and immunohistochemical study of 17 cases

Abstract

We present 17 penile traumatic neuromas. The mean patient age at presentation was 38 years (range 23-59 years). The most common site involved was the penile shaft. The lesions ranged from 1 to 7 mm in greatest dimension. The clinical diagnosis in all cases included condyloma acuminatum. In all cases, a history of trauma because of prior biopsy and/or circumcision was found. Histologically, all lesions showed similar features consisting of an increased number of dermal nerve bundles embedded within a fibrous stroma. Often, single or multiple Meissner corpuscle-like structures were noted in the papillary dermis. Our study suggests that circumcision or other forms of trauma to the skin of the penis likely plays an important role in the pathogenesis and clinical presentation of this peculiar neural neoplasm. We call attention to this entity because it is often clinically misdiagnosed as condyloma acuminatum.

Penile Traumatic Neuroma: A Late Complication of Penile Dorsal Neurotomy to Treat Premature Ejaculation

“…A case series study in 2009 by Salcedo et al 3 reported that traumatic neuromas are caused by circumcision or biopsies. The case of a 23-year-old man reported in 2009 by Marinho and Bouscarat 8 also was a traumatic neuroma secondary to circumcision.…”

“…It forms a nodular proliferation arising from the hyperplasia of axons and nerve sheaths after nerve injury or resection 1, 2, 3. Traumatic neuroma is a disorganized growth of the proximal portion of an injured or resected nerve; it can occur in any lesion, but few have been reported in the penis 2 .…”

“…Traumatic neuroma is a disorganized growth of the proximal portion of an injured or resected nerve; it can occur in any lesion, but few have been reported in the penis 2 . Most reported cases of traumatic neuroma in the penis have been associated with unintended trauma to the nerve during circumcision 3 . However, no reports have been published on traumatic neuroma from nerve resection in the penis to treat premature ejaculation (PE).…”

Subungal traumatic neuroma

“…1,2 The ultimate etiopathology is theorized to be nerve amputation with disorganized attempt at regeneration. These locations include oral mucosa after surgical enhancements, sites of tooth extraction, and in the region of a previous circumcision.…”

Multiple traumatic neuromas after laser ablation treatment for viral warts

“…1 Traumatic neuromas can occur at any site where injury has occurred, resulting in the disorganized growth of the damaged proximal nerve as it fails to reconnect with the distal nerve sheath. 3 In histopathological findings, traumatic neuroma has been found to consist of peripheral nerve fiber proliferating to form variable-sized nerve fascicles in an irregularly arranged pattern. It is well circumscribed by surrounding fibrous tissue.…”