Traumatic brain injury of the forelimb and hindlimb sensorimotor areas in the rat: physiological, histological and behavioral correlates

Soblosky, Joseph S.; Matthews, Murray A.; Davidson, June F.; Tabor, Stacy L.; Carey, Michael E.

doi:10.1016/0166-4328(95)00264-2

Cited by 66 publications

(38 citation statements)

References 49 publications

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“…24,25 We found that the ADC, FA and T 2 changes generally correlated well with functional outcomes. However, there were subtle differences.…”

Section: Correlation With Behavioral and Immunohistological Analysesmentioning

confidence: 78%

“…25 Previous behavioral studies have demonstrated that these functional tests have the appropriate sensitivity for this injury models. [22][23][24] Testing was conducted 1-3 d prior to TBI and again 1, 2, 7, and 14 d post-TBI.…”

Section: Functional Assessmentmentioning

confidence: 99%

“…MRI measurements were made longitudinally from 3 h to up to 14 d post-TBI. Comparisons were made with longitudinal behavioral assessments (foot fault and forelimb asymmetry test) [22][23][24] and end-point histology (Nissl staining).…”

Section: Introductionmentioning

confidence: 99%

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Multiparametric and Longitudinal MRI Characterization of Mild Traumatic Brain Injury in Rats

Long

Watts

Chemello

et al. 2015

Journal of Neurotrauma

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This study reports T 2 and diffusion-tensor magnetic resonance imaging (MRI) studies of a mild open-skull, controlled cortical impact injury in rats (n = 6) from 3 h to up to 14 d after traumatic brain injury (TBI). Comparison was made with longitudinal behavioral measurements and end-point histology. The impact was applied over the left primary forelimb somatosensory cortex (S1FL). The major findings were: 1) In the S1FL, T 2 increased and fractional anisotropy (FA) decreased at 3 h after TBI and gradually returned toward normal by Day 14; 2) in the S1FL, the apparent diffusion coefficient (ADC) increased at 3 h, peaked on Day 2, and gradually returned toward normal at Day 14; 3) in the corpus callosum underneath the S1FL, FA decreased at 3 h to Day 2 but returned to normal at Day 7 and 14, whereas T 2 and ADC were normal throughout; 4) heterogeneous hyperintense and hypointense T 2 map intensities likely indicated the presence of hemorrhage but were not independently verified; 5) lesion volumes defined by abnormal T 2 , ADC, and FA showed similar temporal patterns, peaking around Day 2 and returning toward normal on Day 14; 6) the temporal profiles of lesion volumes were consistent with behavioral scores assessed by forelimb placement and forelimb foot fault tests; and 7) at 14 d post-TBI, there was substantial tissue recovery by MRI, which could either reflect true tissue recovery or reabsorption of edema. Histology performed 14 d post-TBI, however, showed a small cavitation and significant neuronal degeneration surrounding the cavitation in S1FL. Thus, the observed improvement of behavioral scores likely involves both functional recovery and functional compensation.

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“…24,25 We found that the ADC, FA and T 2 changes generally correlated well with functional outcomes. However, there were subtle differences.…”

Section: Correlation With Behavioral and Immunohistological Analysesmentioning

confidence: 78%

Section: Functional Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Multiparametric and Longitudinal MRI Characterization of Mild Traumatic Brain Injury in Rats

Long

Watts

Chemello

et al. 2015

Journal of Neurotrauma

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“…8 Previous behavioral studies have demonstrated that these functional tests have the appropriate sensitivity for this injury model. 17,18 Testing was conducted 1-3 days before TBI and again 1, 2, 7, and 14 days post TBI.…”

Section: Functional Assessmentmentioning

confidence: 99%

The Effects of Perturbed Cerebral Blood Flow and Cerebrovascular Reactivity on Structural MRI and Behavioral Readouts in Mild Traumatic Brain Injury

Long

Watts

et al. 2015

J Cereb Blood Flow Metab

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This study investigated the effects of perturbed cerebral blood flow (CBF) and cerebrovascular reactivity (CR) on relaxation time constant (T 2 ), apparent diffusion coefficient (ADC), fractional anisotropy (FA), and behavioral scores at 1 and 3 hours, 2, 7, and 14 days after traumatic brain injury (TBI) in rats. Open-skull TBI was induced over the left primary forelimb somatosensory cortex (N = 8 and 3 sham). We found the abnormal areas of CBF and CR on days 0 and 2 were larger than those of the T 2 , ADC, and FA abnormalities. In the impact core, CBF was reduced on day 0, increased to 2.5 times of normal on day 2, and returned toward normal by day 14, whereas in the tissue surrounding the impact, hypoperfusion was observed on days 0 and 2. CR in the impact core was negative, most severe on day 2 but gradually returned toward normal. T 2 , ADC, and FA abnormalities in the impact core were detected on day 0, peaked on day 2, and pseudonormalized by day 14. Lesion volumes peaked on day 2 and were temporally correlated with forelimb asymmetry and foot-fault scores. This study quantified the effects of perturbed CBF and CR on structural magnetic resonance imaging and behavioral readouts.

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“…Among the widely implemented assessments in rat TBI studies are tasks that measure postural and locomotor behaviors, such as beam walking and balancing (Dixon et al, 1991;Feeney et al, 1982;Goldstein, 1993;Soblosky et al, 1996). In the present study, we primarily assessed forelimb motor behavior, since we were interested in characterizing deficits resulting from a focal impact injury in the CFA, the rodent equivalent of the primary motor hand area in primates.…”

Section: Behavioral Deficits After CCI In the Rat Motor Cortexmentioning

confidence: 99%

A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

Nudo¹

2011

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY)2 Using a controlled cortical-impact device, we have successfully induced traumatic brain injury (TBI) in the caudal forelimb area (CFA) of the rat brain, sparing the rostral forelimb area (RFA) that is the target for implantation of the electronic microsystem. Behavioral assessments of reaching, retrieval of small food items, and locomotion demonstrate that deficits persist during the 5-week recovery period following injury. Further, an unprecedented, potent effect of activity-dependent stimulation (ADS) between the RFA and primary somatosensory forelimb area in brain-injured rats has been demonstrated by 5 days post-lesion. 28No subject terms provided.

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Traumatic brain injury of the forelimb and hindlimb sensorimotor areas in the rat: physiological, histological and behavioral correlates

Cited by 66 publications

References 49 publications

Multiparametric and Longitudinal MRI Characterization of Mild Traumatic Brain Injury in Rats

Multiparametric and Longitudinal MRI Characterization of Mild Traumatic Brain Injury in Rats

The Effects of Perturbed Cerebral Blood Flow and Cerebrovascular Reactivity on Structural MRI and Behavioral Readouts in Mild Traumatic Brain Injury

A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

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