Transverse trabeculae and osteoporosis in bones in experimental protein-calorie deficiency

Platt, B. S.; Stewart, R. J. C.

doi:10.1079/bjn19620047

“…Diante desses achados, reforça-se a evidência que a desnutrição proteica imposta durante os períodos críticos de desenvolvimento, leva a um déficit no crescimento do animal e que a gravidade dessa lesão está relacionada à fase da vida em que foi induzida, que são períodos determinantes para a formação óssea e o tipo de injúria 23,25 .…”

Section: Discussionunclassified

Effects of physical exercise during pregnancy and protein malnutrition during pregnancy and lactation on the development and growth of the offspring’s femur

Monteiro

¹

,

Paes

²

,

Santos

³

et al. 2010

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Objective: To evaluate the effects of physical training of mother rats during pregnancy associated with a low-protein diet offered during pregnancy and lactation on the development and growth of the femur of their offspring.Methods: Forty 90-day old male Wistar rats were divided into four groups: pups of sedentary nourished mothers, pups of sedentary malnourished mothers, pups of trained nourished mothers, and pups of trained malnourished mothers; all groups included 10 rats. Physical training on a treadmill for 8 weeks, 5 weeks before conception and 3 weeks in the gestational period for mother rats of pups of trained nourished mothers and pups of trained malnourished mothers. Induction of low-protein diet to the mother rats during pregnancy and lactation for the groups of pups of sedentary malnourished mothers and trained malnourished mothers. After the pups were sacrificed, on the 90th day of life, we analyzed weight, length, and femoral bone mineral content.Results: Decreased body weight, femur weight, and femur length (p < 0.05) were observed for the groups of pups of sedentary malnourished mothers and trained malnourished mothers in comparison with to the groups of pups of sedentary nourished mothers and trained nourished mothers, respectively. There was no difference in bone mineral content of the femur in either of the groups. Conclusion:Mild physical training on the treadmill during pregnancy does not interfere with bone development and growth of the offspring. However, protein malnutrition during this period and during lactation promotes permanent damage to the bone structure of the offspring. J Pediatr (Rio J). 2010;86(3):233-238:Physical training, protein malnutrition, pregnancy, post-natal, femur. ResumoObjetivo: Avaliar os efeitos do treino físico imposto às ratas mães durante a gestação associado a uma dieta hipoproteica imposta durante os períodos gestacional e de lactação sobre o desenvolvimento e crescimento do fêmur da prole.Métodos: Quarenta ratos machos Wistar, 90 dias de vida, foram divididos em quatro grupos: filhotes de mãe sedentária nutrida, filhotes de mãe sedentária desnutrida, filhotes de mãe treinada nutrida e filhotes de mãe treinada desnutrida, todos com n = 10. Treinamento físico em esteira durante 8 semanas, 5 semanas antes da concepção e 3 no período gestacional para as ratas mães dos grupos filhotes de mães treinada nutrida e treinada desnutrida. Indução da dieta hipoproteica às ratas mães durante a gestação e lactação para os grupos filhotes de mães sedentária desnutrida e treinada desnutrida. Após sacrifício, no 90º dia de vida, analisou-se peso, comprimento e conteúdo mineral ósseo do fêmur dos filhotes.Resultados: Peso corporal, peso femoral e comprimento femoral diminuídos (p < 0,05) para os grupos filhotes de mães sedentária desnutrida e treinada desnutrida em relação aos grupos filhotes de mães sedentária nutrida e treinada nutrida, respectivamente. Não houve diferença no conteúdo mineral ósseo do fêmur em nenhum dos grupos. Conclusão:O treinamento físico leve em...

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“…In the present study, the femur length of the pups of malnourished mother rats was reduced at 90 days of life. The reduction in the length of long bones, such as the femur, due to a protein deficiency has often been attributed to a decrease in bone formation 25 and a lower rate of appositional bone growth. 26 Physical training during the gestational phase, similarly to the data of body weight and femur weight, did not change the femur length of the pups.…”

Section: Discussionmentioning

confidence: 99%

“…Based on these findings, there is stronger evidence that protein malnutrition imposed during critical developmental periods leads to a stunted growth of the animal and that the severity of this deficit is related to stage of life during which it was induced, which are crucial periods for bone formation and type of impairment. 23,25 Protein malnutrition during pregnancy and lactation promotes permanent damage to the bone structure of the pups. However, the practice of mild physical activity performed by female rats during pregnancy does not intensify the changes in the bone structure of the malnourished offspring or promotes changes in the bones of nourished offspring.…”

Section: Discussionmentioning

confidence: 99%

Repercussões do exercício físico durante a gestação e da desnutrição proteica durante a gestação e lactação sobre o desenvolvimento e crescimento do fêmur da prole

Monteiro¹,

Paes²,

Santos³

et al. 2010

J. Pediatr. (Rio J.)

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Objective: To evaluate the effects of physical training of mother rats during pregnancy associated with a low-protein diet offered during pregnancy and lactation on the development and growth of the femur of their offspring.Methods: Forty 90-day old male Wistar rats were divided into four groups: pups of sedentary nourished mothers, pups of sedentary malnourished mothers, pups of trained nourished mothers, and pups of trained malnourished mothers; all groups included 10 rats. Physical training on a treadmill for 8 weeks, 5 weeks before conception and 3 weeks in the gestational period for mother rats of pups of trained nourished mothers and pups of trained malnourished mothers. Induction of low-protein diet to the mother rats during pregnancy and lactation for the groups of pups of sedentary malnourished mothers and trained malnourished mothers. After the pups were sacrificed, on the 90th day of life, we analyzed weight, length, and femoral bone mineral content.Results: Decreased body weight, femur weight, and femur length (p < 0.05) were observed for the groups of pups of sedentary malnourished mothers and trained malnourished mothers in comparison with to the groups of pups of sedentary nourished mothers and trained nourished mothers, respectively. There was no difference in bone mineral content of the femur in either of the groups. Conclusion:Mild physical training on the treadmill during pregnancy does not interfere with bone development and growth of the offspring. However, protein malnutrition during this period and during lactation promotes permanent damage to the bone structure of the offspring.

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“…AUFDERHEIDE et al 1998;CAMPILLO 2001;ROBERTS et al 2005) (PLATT et al 1962;CHHEM et al 2008). Los diagnós-ticos diferenciales y las marcas pseudopatológicas fueron consultadas con al menos otro experto.…”

Section: ; Rissech Carme Et Al 2013)unclassified

“…En el análisis de la muestra de sedimento de la zona torácica del enterramiento de la tumba1 se han encontrado fitolitos, primariamente de tipo Pooideae, y en una proporción menor al 5% de Panicoideae, que podrían relacionare con los restos digestivos del contenido esofágico (PORTILLO et al 2013). La limitación del muestro ante la falta de sedimentos no asociados al inhumado para su contrastación hace que debamos tomar esta interpretación con cautela (PORTILLO et al 2013 PLATT et al 1962;GOODMAN et al 1990). No se puede afirmar que este individuo se criase en la fortaleza, por tanto, no es posible vincular el posible estrés nutricional a la variedad de alimentos hallada en la misma.…”

Section: Díaz Y Díaz 1983unclassified

Condiciones de vida reconstruidas mediante el estudio de los restos humanos hallados en la fortaleza Bajomedieval de A Rocha Forte, Santiago de Compostela

López-Costas

¹

,

Brión

²

2015

Gall

1

0

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ResumenDurante la campaña de excavaciones del año 2013, se halló parte de una posible necrópolis medieval (1300-1400 d C.) en la fortaleza santiaguesa de A Rocha Forte. Los restos humanos encontrados fueron estudiados mediante análisis osteológicos, paleopatológicos y tafonómicos. Se determinó un mínimo de tres individuos adultos jóvenes probablemente masculinos, los cuales mostraban marcas patológicas de haber tenido una vida dura (infecciones crónicas, déficits nutricionales en la infancia, etc.). Este yacimiento fue habitado durante un periodo bien documentado, por lo que el análisis antropológico se complementa con un contexto histórico bien definido. Este estudio permite acercarnos a las condiciones de vida de un castillo medieval en el noroeste Ibérico. Palabras claveFortaleza medieval; necropolis; enterramientos aislados; hipoplasia de esmalte; líneas de Harris. AbstractThe archaeological works that took place in 2013 within the A Rocha Forte castle -Santiago de Compostela, NW Spain discovered part of a medieval necropolis (dating between AD 1300 and 1400). Complete osteological, paleopathological and taphonomical analyses were performed in human remains from three burials. A minimum number of three male individuals, who may have died at young age,was estimated. Their pathological features suggest hard life conditions (infectious diseases, nutritional deficiencies during infancy, etc.). The site was settled during a well-known and relatively short period; therefore, the study of the burials is supported by a welldefined historical context. Both are used to reconstruct the everyday life in a NW Spain medieval castle.

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Transverse trabeculae and osteoporosis in bones in experimental protein-calorie deficiency

Cited by 96 publications

References 24 publications

Effects of physical exercise during pregnancy and protein malnutrition during pregnancy and lactation on the development and growth of the offspring’s femur

Effects of physical exercise during pregnancy and protein malnutrition during pregnancy and lactation on the development and growth of the offspring’s femur

Repercussões do exercício físico durante a gestação e da desnutrição proteica durante a gestação e lactação sobre o desenvolvimento e crescimento do fêmur da prole

Condiciones de vida reconstruidas mediante el estudio de los restos humanos hallados en la fortaleza Bajomedieval de A Rocha Forte, Santiago de Compostela

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