Marco De Cecco, Steven W. Criscione, Abigail L. Peterson, Nicola Neretti, John M. Sedivy, Jill A. Kreiling
Abstract:Transposable elements (TEs) were discovered by Barbara McClintock in maize and have since been found to be ubiquitous in all living organisms. Transposition is mutagenic and organisms have evolved mechanisms to repress the activity of their endogenous TEs. Transposition in somatic cells is very low, but recent evidence suggests that it may be derepressed in some cases, such as cancer development. We have found that during normal aging several families of retrotransposable elements (RTEs) start being transcribe…
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