Transport of Very Low Density Lipoprotein Triglycerides in Varying Degrees of Obesity and Hypertriglyceridemia

Grundy, Scott M.; Mok, Henry; Zech, Loren A.; Steinberg, Daniel; Berman, Mones

doi:10.1172/jci109422

Cited by 271 publications

(116 citation statements)

References 47 publications

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“…Furthermore, 24 recorded results which were consistent with the results of the current study for the level of HDL, LDL has earned a morale levels and, on the other hand his results contrasted the findings of the results of our study in each of the TG and TC. The results of our study agreed with 25 in the levels of each of the TC, HDL, TG, VLDL except LDL level was not significant. This is a contradiction with what we got in our study.…”

Section: Discussionsupporting

confidence: 89%

A Study of Serum Lipid Profile among Obese and Non-Obese Individuals: A Hospital based Study from Karbala, Iraq

Aljaffar¹

2018

IJCMR

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Introduction: Obesity is a multifactor disorder and its development is due to multiple interactions between genes and environment. This study aims at measuring and correlating values of serum triglyceride level in obese and non-obese individuals. Material and methods: Total Sixty five individuals of the age group between 20-70 yrs, coming for health checkup at AlHussain teaching hospital, were selected for the study. They were divided into groups. One group having BMI more than 30 considered as obese group, another group with BMI less than 25 considered as non-obese group. Fasting blood samples were analyzed for blood cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), using chemistry analyzer, BS-300 Chemistry Analyzer Results: A significant increase in levels of serum cholesterol and serum LDL -C and a significant decrease HDL-C in obese woman and men were observed. The adult obese has relatively larger changes in serum lipids at any given level of obesity. The study has documented several lipid profile abnormalities among obese and non-obese patients. The study revealed that obesity was high among woman patients and required special attention. Conclusion:The study concluded that, the presence of statistically significant changes in the proportions of fat, which is considered a risk factor for blood vessel and obese in Iraqi's Men and Women.

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Section: Discussionsupporting

confidence: 89%

A Study of Serum Lipid Profile among Obese and Non-Obese Individuals: A Hospital based Study from Karbala, Iraq

Aljaffar¹

2018

IJCMR

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“…A common method for normalizing VLDL-TG transport data is to express them as mg/hr/kg of total body weight. However, as recently shown by Grundy et al, 11 calculation of transport rates per kilogram of total body weight can be misleading. In obese subjects, this decreases transport to inordinately low values, as compared to absolute transports.…”

Section: Transport Of Vldl-tgmentioning

confidence: 94%

Triglyceride and cholesterol metabolism in primary hypertriglyceridemia.

Beil¹,

Grundy²,

Crouse³

et al. 1982

Arteriosclerosis

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To determine mechanisms of elevated plasma trlglycerldes (TG) in patients with primary hypertrlglyceridemlas, simultaneous studies were carried out on kinetics of very low density llpoproteln-triglycerides (VLDL-TG) and synthesis of cholesterol and bile acids. Sixteen hypertrlglyceridemlc patients with familial combined hyperllpldemla (FCHL) and 12 patients with poorly classified, primary hypertriglyceridemia were studied, and their results were compared to a series of normal and obese subjects previously studied In our laboratory. The mean value for transport (synthesis) of VLDL-TG in patients with FCHL was about twice normal. Although the upper normal synthesis rates overlapped with transport rates of some patients with FCHL, It appeared that the major cause of hypertriglyceridemia in FCHL was an elevated production of VLDL-TG. However, the height of the plasma TG in FCHL patients also was influenced by Individual clearance capacities for VLDL-TG, and fractional clearance rates In several seemed particularly low. Synthesis rates for cholesterol and/or bile acids were high In several patients with FCHL, suggesting simultaneous overproduction of VLDL-TG and sterols; however, Increased synthesis of both was not observed In all the patients. Most patients with poorly classified hypertriglyceridemia had overproduction of VLDL-TG, but an apparent reduction in clearance was common. In these patients, Increased synthesis of cholesterol and bile acids was Infrequent. Our results indicate that abnormally high production of VLDL-TG seemed to be the major factor In causing primary hypertriglyceridemia, but that clearance capacity can play an important role In determining the severity of the TG elevation. (Arteriosclerosis 2:44-57, January/February 1982)

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“…It raises the blood pressure, increases VLDL, 5 and lowers HDL. 9 These changes may impart an increased risk for coronary heart disease (CHD).…”

Section: Obesity Apoldl Metabolism and Coronary Heart Diseasementioning

confidence: 99%

“…Synthetic rates of cholesterol and bile acid are increased in obese subjects, 1 " 4 as are production rates of very low density lipoprotein-triglycerides (VLDL-TG). 5 " 7 Since VLDL is a precursor of low density lipoproteins (LDL), 89 overproduction of VLDL might be expected to increase LDL. Many obese subjects, however, have normal concentrations of plasma cholesterol and LDL-cholesterol.…”

mentioning

confidence: 99%

Increased low density lipoprotein production associated with obesity.

Kesäniemi¹,

Grundy²

1983

Arteriosclerosis

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Turnover rates of the apolipoprotein of low density lipoproteins (apoLDL) and cholesterol balance were determined in six obese men and six control men. The two groups were of similar age and matched for apoLDL concentrations. Levels of plasma total cholesterol in obese patients (209 ± 14 SEumg/dl) were similar to controls (225 ± 17 mg/dl). LDL-cholesterol was numerically but not statistically lower in obese subjects (111 ± 18 mg/dl) compared to controls (145 ± 13 mg/dl). Synthetic rates of apoLDL in contrast were higher in obese patients (1450 mg/day) than in controls (934 mg/day) (p < 0.002). Three factors could explain the similar concentrations of LDLcholesterol in obese and control subjects, despite overproduction of apoLDL in the obese. First, LDL was diluted into a larger plasma pool in obese patients; second, fractional catabolic rates of apoLDL were somewhat greater in obese men than in controls; and third, obese patients had higher ratios of protein-to-cholesterol in LDL. The production of apoLDL for all patients was not correlated with total body synthesis of cholesterol. The major finding of this study was that obese patients have increased turnover of apoLDL, not necessarily reflected by high concentrations of LDL-cholesterol. This high turnover rate itself may raise the risk for coronary heart disease in obese patients. (Arteriosclerosis 3:170-177, March/April 1983)

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Transport of Very Low Density Lipoprotein Triglycerides in Varying Degrees of Obesity and Hypertriglyceridemia

Cited by 271 publications

References 47 publications

A Study of Serum Lipid Profile among Obese and Non-Obese Individuals: A Hospital based Study from Karbala, Iraq

A Study of Serum Lipid Profile among Obese and Non-Obese Individuals: A Hospital based Study from Karbala, Iraq

Triglyceride and cholesterol metabolism in primary hypertriglyceridemia.

Increased low density lipoprotein production associated with obesity.

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