Transplanted human cord blood-derived unrestricted somatic stem cells improve left-ventricular function and prevent left-ventricular dilation and scar formation after acute myocardial infarction

Ghodsizad, Ali; Niehaus, Michael; Kögler, Gesine; Martin, Ulrich; Wernet, Peter; Bara, Christoph; Khaladj, Nawid; Loos, Anja H.; Makoui, M; Thiele, Jüergen; Mengel, Michael; Kretzler, Matthias; Klein, Hans-Martin; Haverich, Axel; Ruhparwar, Arjang

doi:10.1136/hrt.2007.139329

Cited by 57 publications

(44 citation statements)

References 30 publications

(21 reference statements)

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“…This was associated with a significant improvement of left ventricular ejection fraction and it prevented left ventricular dilation. 67 We were not able to confirm USSC graft survival and USSC differentiation toward cardiomyocytes. However, with 10 8 USSC used for engraftment in the study by Kim et al, the cell number exceeded ours significantly (1.2 Â 10 7 ).…”

Section: Implication Of Cb For Cardiovascular Regenerative Medicinementioning

confidence: 66%

“…67 Although no human cells were detectable 2 months after transplantation, the USSC preserved the recipient myocardium and prevented scar formation after acute ischemia. This was associated with a significant improvement of left ventricular ejection fraction and it prevented left ventricular dilation.…”

Section: Implication Of Cb For Cardiovascular Regenerative Medicinementioning

confidence: 99%

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Future of cord blood for non-oncology uses

Kögler

Critser

Trapp

et al. 2009

Bone Marrow Transplant

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Section: Implication Of Cb For Cardiovascular Regenerative Medicinementioning

confidence: 66%

Section: Implication Of Cb For Cardiovascular Regenerative Medicinementioning

confidence: 99%

Future of cord blood for non-oncology uses

Kögler

Critser

Trapp

et al. 2009

Bone Marrow Transplant

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“…Patient's lifelong exposure to risk factors contributing to ischemic heart disease (ie, age, diabetes mellitus, and smoking) may impair the potential of autologous stem cells. [11][12][13] Restricted availability is present because selection and culturing of sufficient potent cells is cumbersome and time consuming. This limitation is especially important in the acute setting of myocardial ischemia.…”

mentioning

confidence: 99%

Similar Effect of Autologous and Allogeneic Cell Therapy for Ischemic Heart Disease

Eding

Vesterinen

Spoel

et al. 2015

Circulation Research

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Rationale:In regenerative therapy for ischemic heart disease, use of both autologous and allogeneic stem cells has been investigated. Autologous cell can be applied without immunosuppression, but availability is restricted, and cells have been exposed to risk factors and aging. Allogeneic cell therapy enables preoperative production of potent cell lines and immediate availability of cell products, allowing off-the-shelf therapy. It is unknown which cell source is preferred with regard to improving cardiac function.Objective: We performed a meta-analysis of preclinical data of cell therapy for ischemic heart disease. Methods and Results:We conducted a systematic literature search to identify publications describing controlled preclinical trials of unmodified stem cell therapy in large animal models of myocardial ischemia. Data from 82 studies involving 1415 animals showed a significant improvement in mean left ventricular ejection fraction in treated compared with control animals (8.3%, 95% confidence interval, 7.1-9.5; P<0.001). Meta-regression revealed a similar difference in left ventricular ejection fraction in autologous (8.8%, 95% confidence interval, 7.3-10.3; n=981) and allogeneic (7.3%, 95% confidence interval, 4.4-10.2, n=331; P=0.3) cell therapies. Conclusions: Autologous and allogeneic cell therapy for ischemic heart disease show a similar improvement in

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“…USSC have been shown to enable reconstitution of femoral defects in mice 3,5,52 and to improve heart function after myocardial infarctions. 3,7,53,54 In this study, mesodermal differentiation capacity of the clones was confirmed by the ability of the cells to mineralize after culturing in medium that induces stem cells down the osteogenic differentiation pathway. Distinct clusters of Alizarin Red S-stained cells were observed in both clones confirming successful mineralization.…”

Section: Discussionmentioning

confidence: 86%