2000
DOI: 10.1002/(sici)1098-1136(200005)30:3<209::aid-glia1>3.0.co;2-8
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Abstract: Human olfactory ensheathing cells (OECs) were prepared from adult human olfactory nerves, which were removed during surgery for frontal base tumors, and were transplanted into the demyelinated spinal cord of immunosuppressed adult rats. Extensive remyelination was observed in the lesion site: In situ hybridization using a human DNA probe (COT-1) indicated a similar number of COT-1positive cells and OEC nuclei within the repaired lesion. The myelination was of a peripheral type with large nuclei and cytoplasmic… Show more

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Cited by 207 publications
(133 citation statements)
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“…These cells are unique in that they continue to arise in the olfactory epithelium from which they can migrate to the olfactory bulb throughout life [232][233][234]. Rodent and human OECs generate Schwann-cell-like myelin and improve conduction properties when transplanted to areas of demyelination in the brain or spinal cord [227,233,[235][236][237][238][239][240]. OECs also have the capacity to promote axonal growth [241] and to secrete neurotrophic molecules [242,243].…”
Section: Olfactory Nerve Ensheathing Cellsmentioning
confidence: 99%
“…These cells are unique in that they continue to arise in the olfactory epithelium from which they can migrate to the olfactory bulb throughout life [232][233][234]. Rodent and human OECs generate Schwann-cell-like myelin and improve conduction properties when transplanted to areas of demyelination in the brain or spinal cord [227,233,[235][236][237][238][239][240]. OECs also have the capacity to promote axonal growth [241] and to secrete neurotrophic molecules [242,243].…”
Section: Olfactory Nerve Ensheathing Cellsmentioning
confidence: 99%
“…Recently, most studies have defined the purity of different animal as well as human OEC cultures based on sole on the proporting of p75NTR immunostaining (Barnett et al, 2000;Kato et al, 2000). We also determined the percentage of the fetal human OB cells in culture in this article, the P75NTR-positive OECs were 22.31, GFAP-positive OB-cells were 31.93, and S100b-positive OB-cells were 45.77 (Table 2).…”
Section: The Characterization Of Human Fetal Ob-oecs In Cell Culture mentioning
confidence: 99%
“…Olfactory ensheathing cells (OECs) elicit remyelination of demyelinated spinal axons Kato et al, 2000), restore central nerve conduction (Imaizumi et al, 1998(Imaizumi et al, , 2000, and promote axonal regeneration (Li et al, 1998;Imaizumi et al, 2000;Ramón-Cueto et al, 2000;Lu et al, , 2002 after transplantation in lesioned spinal cords. Significant recovery of motor and sensory functions was reported in OECs-transplanted rats compared with DMEM-injected animals after complete spinal cord transection (Ramón-Cueto et al, 2000;Lu et al, , 2002.…”
Section: Introductionmentioning
confidence: 99%