Transplantation of Bone Marrow Cells Preactivated With Sodium Nitroprusside Improves Acute Wound Healing in Rabbits

Fatima, Nazira; Saleem, Muhammad

doi:10.1177/15347346211029078

Cited by 3 publications

(6 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Growth factors are dependable for mobilizing, stimulating, and activating of SCs from the BM. In our previous study, the regeneration of specific tissue in that area depends on the specific growth factor and optimum doses of NaNP with BMCs that enhance WH [26]. So the SC research tells about the proper sequence of growth factors i. e. needed for specific tissue regeneration [39].…”

Section: Discussionmentioning

confidence: 98%

“…Pretreatment of b.M cells Added NaNP as an induction factor to BMCs suspension for the increase of differentiation potential of a cell, about 50 µL & 100 µL from the stock solution [26].…”

Section: Wound Healing Percentage In Nth Day= × 100mentioning

confidence: 99%

“…With the help of the ELISA Test, different samples were assessed for their content of specific growth factors. Collagen type 1 (CoL-1) and VEGF were measured per manufacturer's instructions: (kits from R &D System, Abcam, and My BioSource), on days 5, 10, and 15 [26].…”

Section: Elisa Assaysmentioning

confidence: 99%

See 2 more Smart Citations

Improvement of Chronic Wound Healing by Pre-activated Bone Marrow Cells with Sodium Nitroprusside in Rabbits

Fatima

Saleem

Shahbaz³

2021

Drug Res (Stuttg)

View full text Add to dashboard Cite

Aim of study This study investigated whether pre-activated bone marrow cells with sodium nitro prusside have effectiveness in the inhibition of diabetic wound healing in diabetic rabbits. In diabetic skin disorders and conditions involved redox state disturbances. The aim was to determine the effect of two minimum dosages of sodium nitro prusside, and its’ potential with bone marrow cells for chronic wound healing in-vivo. Methods Full-thickness skin dorsal wounds were created on diabetic rabbits. The effects of two minimum concentrations of sodium nitro prusside solution with bone marrow cells on wound healing were studied. The useful combination of sodium nitro prusside with bone marrow cells on wound repair may be attributed to its functional influences on inflammation, angiogenesis, cell proliferation, matrix deposition, and remodeling. Results The in-vivo experiments confirmed that pre-activated bone marrow cells contributed to wound healing by alleviating oxidative stress, increasing proliferation and migration, decreasing apoptosis. In histological results, improved collagen deposition, enhanced re-epithelization, angiogenesis, and decreased inflammatory infiltration were also detected in wound biopsies. Conclusions For the treatment of chronic wounds, cell-based therapy was an attractive approach. Bone marrow cells have a low ability to differentiate various types of cells or late healing without pretreatment. So it was needed to increase their potency of differentiation. The transplantation of pretreated bone marrow cells with a prime quantity of sodium nitro prusside solution improved chronic wound healing with a greater level of growth factors and a minimum level of oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Wound Healing Percentage In Nth Day= × 100mentioning

confidence: 99%

See 1 more Smart Citation

Improvement of Chronic Wound Healing by Pre-activated Bone Marrow Cells with Sodium Nitroprusside in Rabbits

Fatima

Saleem

Shahbaz³

2021

Drug Res (Stuttg)

View full text Add to dashboard Cite

show abstract

“…It was reported that BM-derived stem cells may be involved in the acceleration of wound healing ( Wu et al ., 2007 ) including burn injury ( Xue et al ., 2013 ). It was recently reported also that transplantation of BM cells pre-activated with sodium nitroprusside enhances acute wound curing in rabbits ( Fatima and Saleem, 2023 ). Parelle, enhancement of chronic wound curing by pre-activated BM cells with sodium nitroprusside in rabbits has been reported ( Fatima et al ., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of pomegranate peel with/without autologous bone marrow on healing of acute cutaneous wounds in alloxan-induced diabetic rabbits

Sobayil,

Alsupail,

Tharwat

2024

Open Vet J

View full text Add to dashboard Cite

Background: Healing of bum wounds is a commonly associated with many complications. Every year various new repair materials are developed and experimentally used for treating burn wounds. Humans with diabetes mellitus usually suffer from chronic wound healing. Vascular, neuropathic, immune function, and biochemical abnormalities each contribute to the altered tissue repair. One underlying factor that accompanies all diabetic ulcerations is poor vascular flow, a circumstance that impedes proper wound healing. Numerous studies have highlighted the importance of adequate vascular sufficiency and vessel proliferation in tissue repair and the lack thereof in diabetic wound healing. Other studies have looked at whether disarrayed capillary remodeling and maturation of vessels might play a role in impaired diabetic wound healing. Aim: This investigation has been planned to report the influence of treatment with a mixture of both the powder of pomegranate peel accompanied with an autologous bone marrow on cure of burn injuries in experimentally induced diabetic rabbits. Methods: Alloxan monohydrate has been applied to create diabetes in 50 rabbits. Then in each rabbit, two deep second-degree burn wounds were experimentally created. The animals were then divided randomly into 5 treatment sections: non-treatment controls (C1), treated with an available commercial powder for wound (C2), treatment with powder of pomegranate peel (PP), treatment with bone marrow alone (BM), and final group treated with PP powder with bone marrow (PPBM). The speed of wound closure and the histopathological changes during healing were measured. The levels of the biomarkers of rabbit platelet derived growth factor AA (PDGF-AA) and rabbit protease activated receptor 1 (PAR-1) were measured on days 0, 4, 8 and 12. Results: Wounds healing was markedly more rapid in all the treatment groups versus the control non-treated group. Interestingly, a rapid wound cure was significantly observed in PPBM group versus the other treatment ones. The histological assessment clarified a significant elevation in the fibroblast and collagen scores in PPBM group versus the other sections. In addition, there were significant increases in the serum levels of the biomarkers PDGF-AA and PAR-1 among groups. Conclusion: Dependent on the results of current research, it can be concluded that both PP powder with BM (PPBM) significantly accelerate healing process of burn wounds in experimentally induced diabetic rabbits.

show abstract

“…Sodium nitroprusside has a wide range of pharmaceutical applications. Because of its ability to release NO, sodium nitroprusside can dilate blood vessels and regulate wound healing [11]. In recent years, AgNP NPs have shown potential for medical applications due to their excellent physicochemical properties, antimicrobial properties, and biocompatibility [12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Starch-Based Ag2[Fe (CN)5NO] Nanoparticles for Utilization in Antibacterial and Wound-Dressing Applications

Lu,

Sathiyaseelan,

Zhang

et al. 2024

Antioxidants

View full text Add to dashboard Cite

Bacterial infections can lead to the formation of chronic wounds and delay the wound-healing process. Therefore, it is important to explore safe and efficient antimicrobial agents that have wound-healing and biocompatible properties. In this study, novel starch-fabricated silver nitroprusside nanoparticles (S-AgNP NPs) were prepared for biocompatible wound-healing applications. The study showed that S-AgNP NPs are spherical, with an average size of 356 ± 22.28 d. nm and zeta potential of −27.8 ± 2.80 mV, respectively. Furthermore, the FTIR and XRD results showed that S-AgNP NPs have functional groups and crystal structures from the silver nitroprusside nanoparticles (AgNP NPs) and starch. Additionally, S-AgNP NPs showed excellent bacterial and biofilm inhibition on B. cereus (15.6 μg/mL), L. monocytogenes (15.6 μg/mL), S. aureus (31.3 μg/mL), E. coli (31.3 μg/mL) and S. enterica (62.5 μg/mL). Moreover, S-AgNP NPs promoted cell migration and proliferation at a concentration of 62.5 μg/mL compared to AgNP NPs. Meanwhile, S-AgNP NPs had good biocompatibility and low cytotoxicity compared to AgNP NPs. Therefore, this study provided new ideas for the development of wound-healing agents with bacteriostatic properties in chronic wounds.

show abstract

Transplantation of Bone Marrow Cells Preactivated With Sodium Nitroprusside Improves Acute Wound Healing in Rabbits

Cited by 3 publications

References 43 publications

Improvement of Chronic Wound Healing by Pre-activated Bone Marrow Cells with Sodium Nitroprusside in Rabbits

Improvement of Chronic Wound Healing by Pre-activated Bone Marrow Cells with Sodium Nitroprusside in Rabbits

Effect of pomegranate peel with/without autologous bone marrow on healing of acute cutaneous wounds in alloxan-induced diabetic rabbits

Synthesis of Starch-Based Ag2[Fe (CN)5NO] Nanoparticles for Utilization in Antibacterial and Wound-Dressing Applications

Contact Info

Product

Resources

About