1963
DOI: 10.1001/archderm.1963.01590240158027
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Transplantation of Basal Cell Epithelioma to the Rabbit

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1966
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Cited by 37 publications
(17 citation statements)
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“…As with other solid tumors, the environment is critical for their survival, given that tumor cells that are transplanted without their stroma die within a few days …”
Section: Discussionmentioning
confidence: 99%
“…As with other solid tumors, the environment is critical for their survival, given that tumor cells that are transplanted without their stroma die within a few days …”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, transplants including stroma survived and enlarged. In 1963, Gerstein placed sections of basal cells in the anterior chambers of the eyes of rabbits 24 . In 26 out of 28 rabbits, the tumor became necrotic; in the remaining two, the tumor was still present at 3 months but did not show a tendency for growth.…”
Section: Discussionmentioning
confidence: 99%
“…5 Viral therapy of cancer using oncolytic viruses, such as herpes simplex virus (HSV) type 1 (HSV-1) and adenovirus (AD), has been extensively studied in recent years and high selectivity of the viruses in different tumour tissues was demonstrated. [17][18][19][20][21][22][23][24][25][26][27] The lack of predictive models for BCC and SCC delays the assessment of new treatments for these prevalent skin tumours. [11][12][13][14][15] Cells in monolayer culture or three-dimensional cultures using collagen matrices are helpful 16 but they do not recapitulate the three-dimensional structure of a native tissue, that includes several cell types and a variety of extracellular matrix molecules required for the functionality of tissues.…”
Section: Discussionmentioning
confidence: 99%
“…[17][18][19][20][21][22][23][24][25][26][27] To the best of our knowledge, established cell lines for BCC are also not available. Although several groups have attempted to develop animal models of these skin tumours by implanting primary tumours in immune-deficient mice, there are currently no relevant animal models of NMSC available.…”
Section: Discussionmentioning
confidence: 99%