Transplantation Immunology

Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv; Baker, David L.

doi:10.1016/b978-1-4160-3123-9.50025-5

Cited by 187 publications

(379 citation statements)

References 22 publications

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“…iNOS cataly�es arginine conversion to citrullin and produced nitric oxide. In phagolysosome, nitric oxide, hydrogen peroxide and superoxide form peroxynitrite radicals to kill pathogen (Abbas et al, 2012). In cells/tissues, nitric oxide is not stable and has very short half life (Zhang et al, 2011).…”

Section: Nitrite Concentrationmentioning

confidence: 99%

“…Reactive oxygen intermediates such as superoxide radical, hydroxyl radical, and single oxygen are needed to kill pathogen along with nitric oxide (Abbas et al, 2012) but excessive hydroxyl radical can make reaction with poly unsaturated fatty acid to form malondialdehyde. In this research, adding polysacchathis research, adding polysacchathis research, adding polysaccharesearch, adding polysaccharesearch, adding polysacchaadding polysacchaadding polysaccharide krestin showed difference on nitrite concentration among groups.…”

Section: Nitrite Concentrationmentioning

confidence: 99%

“…During phagocytosis, reactive oxy-. During phagocytosis, reactive oxygen intermediates and nitric oxide in the form of peroxynitrite radicals has able to kill pathogen (Abbas et al, 2012). Reactive oxygen interme-., 2012).…”

Section: Introductionmentioning

confidence: 99%

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Influence of Polysaccharide Krestin from Coriolus versicolor Extract on Nitrite and Malondialdehyde Concencentrations of Mus musculus Serum Exposed by Mycobacterium tuberculosis

2016

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Mycobacterium tuberculosis is a major infection agent of tuberculosis that is controlled by the response of cell-mediated immunity. It is macrophages and cytolytic T lymphocytes. Activated macrophages will produce free radicals. Excessive free radicals cause tissue damage. Polysaccharide krestin contains β-glucan. It is a scavenger of free radicals. This research aimed to identify the influence of polysaccharide krestin from C. versicolor on nitrite and malondialdehyde concentrations of mice serum exposed by M. tuberculosis. Nitrite concentration was determined by nitrite assay. Malondialdehyde concentration was determined by TBARS assay. The result showed that adding polysaccharide krestin before exposure (P1) and adding polysaccharide krestin before-after exposure (P3) had the best potential to decrease nitrite concentration. Nitrite concentrations of P1 and P3 were 1.364 ± 0.523 M and 1.456 ± 0.712 M respectively. Meanwhile, P1 group and adding polysaccharide krestin after exposure (P2) had the best potential to decrease malondialdehyde con-con-concentration. Malondialdehyde concentrations of P1 and P2 were 1125.86 ± 97.96 µM and 953.86 ± 328.16 µM respectively. Their nitrite and malondialdehyde con-.86 ± 328.16 µM respectively. Their nitrite and malondialdehyde con-86 ± 328.16 µM respectively. Their nitrite and malondialdehyde con-.16 µM respectively. Their nitrite and malondialdehyde con-16 µM respectively. Their nitrite and malondialdehyde conrespectively. Their nitrite and malondialdehyde con-. Their nitrite and malondialdehyde conconconcentrations decreased, compared to K and K-groups. The research conclusion was that adding polysaccharide krestin before exposure could decrease both nitrite and malondialdehyde concentrations.

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Section: Nitrite Concentrationmentioning

confidence: 99%

Section: Nitrite Concentrationmentioning

confidence: 99%

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Influence of Polysaccharide Krestin from Coriolus versicolor Extract on Nitrite and Malondialdehyde Concencentrations of Mus musculus Serum Exposed by Mycobacterium tuberculosis

2016

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“…However, immune reactions can vary. Neutralizing antibodies can also be generated which effectively bind the protein and facilitate its degradation [82]. However, it is also possible that type I immediate hypersensitivity reactions can be initiated which result in anaphylaxis [82].…”

Section: Entry Inhibitorsmentioning

confidence: 99%

“…Accordingly, exposure to the protein can activate T and 8 cells, initiating an immune reaction [82]. However, immune reactions can vary.…”

Section: Entry Inhibitorsmentioning

confidence: 99%

Profile of systemic treatment with the antiviral lectin Griffithsin in guinea pigs.

Barton¹

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Immunity‐on‐a‐Chip: Integration of Immune Components into the Scheme of Organ‐on‐a‐Chip Systems

Ramadan

Hazaymeh²,

Zourob

2023

Advanced Biology

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Studying the immune system in vitro aims to understand how, when, and where the immune cells migrate/differentiate and respond to the various triggering events and the decision points along the immune response journey. It becomes evident that organ‐on‐a‐chip (OOC) technology has a superior capability to recapitulate the cell‐cell and tissue‐tissue interaction in the body, with a great potential to provide tools for tracking the paracrine signaling with high spatial‐temporal precision and implementing in situ real‐time, non‐destructive detection assays, therefore, enabling extraction of mechanistic information rather than phenotypic information. However, despite the rapid development in this technology, integration of the immune system into OOC devices stays among the least navigated tasks, with immune cells still the major missing components in the developed models. This is mainly due to the complexity of the immune system and the reductionist methodology of the OOC modules. Dedicated research in this field is demanded to establish the understanding of mechanism‐based disease endotypes rather than phenotypes. Herein, we systemically present a synthesis of the state‐of‐the‐art of immune‐cantered OOC technology. We comprehensively outlined what is achieved and identified the technology gaps emphasizing the missing components required to establish immune‐competent OOCs and bridge these gaps.

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Transplantation Immunology

Cited by 187 publications

References 22 publications

Influence of Polysaccharide Krestin from Coriolus versicolor Extract on Nitrite and Malondialdehyde Concencentrations of Mus musculus Serum Exposed by Mycobacterium tuberculosis

Influence of Polysaccharide Krestin from Coriolus versicolor Extract on Nitrite and Malondialdehyde Concencentrations of Mus musculus Serum Exposed by Mycobacterium tuberculosis

Profile of systemic treatment with the antiviral lectin Griffithsin in guinea pigs.

Immunity‐on‐a‐Chip: Integration of Immune Components into the Scheme of Organ‐on‐a‐Chip Systems

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