Transplacental Transmission of a North American Isolate of Leishmania infantum in an Experimentally Infected Beagle

Rosypal, Alexa C.; Troy, Gregory C.; Zajac, Anne M.; Frank, Glenn; Lindsay, David S.

doi:10.1645/ge-483r.1

Cited by 122 publications

(93 citation statements)

References 25 publications

(9 reference statements)

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“…Congenital transmission from infected, pregnant female foxhounds to their pups was observed by owners and reported during the course of our investigation. Transplacental transmission in an experimentally infected beagle was recently described by Rosypal et al ( 18 ). Breeding that results in transplacental infection of litters may be the most important mechanism of transmission among foxhounds, which explains why this infection is limited to foxhounds even in situations in which foxhounds are housed with beagles and basset hounds (data not shown).…”

Section: Discussionmentioning

confidence: 91%

Canine Visceral Leishmaniasis, United States and Canada, 2000–2003

Duprey

Steurer

Rooney

et al. 2006

Emerg. Infect. Dis.

174

173

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Section: Discussionmentioning

confidence: 91%

Canine Visceral Leishmaniasis, United States and Canada, 2000–2003

Duprey

Steurer

Rooney

et al. 2006

Emerg. Infect. Dis.

174

173

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“…In male dogs, several studies have demonstrated the tropism of L. infantum in genital organs (DINIZ et al, 2005). However, few studies previous studies have demonstrated L. infantum tropism in female genital organs of the correlation between parasite load and the onset of lesions in these organs (DUBEY et al, 2005;ROSYPAL et al, 2005;SILVA et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Transmission occurs through the bite of sandflies infected with this protozoon (BARATA et al, 2004). However, vertical transmission (DUBEY et al, 2005;ROSYPAL et al, 2005;PANGRAZIO et al, 2009) and venereal transmission (NAUCKE & LORENTZ, 2012) should also be considered.…”

Section: Considerando a Falta De Estudos Sobre Lesões Nos óRgãos Genimentioning

confidence: 99%

“…Lesions related to VL have been described less frequently in the genital system of dogs in comparison to other organs (DUBEY et al, 2005;ROSYPAL et al, 2005;OLIVEIRA et al, 2012). L. infantum amastigotes have been described in the uterus (ROSYPAL et al, 2005), placenta (DUBEY et al, 2005), vulva and vaginal mucosa.…”

Section: Considerando a Falta De Estudos Sobre Lesões Nos óRgãos Genimentioning

confidence: 99%

“…L. infantum amastigotes have been described in the uterus (ROSYPAL et al, 2005), placenta (DUBEY et al, 2005), vulva and vaginal mucosa. The presence of the parasite in the vulva and vaginal mucosa is related to multifocal chronic inflammatory infiltrate within macrophages, lymphocytes and plasma cells (SILVA et al, 2008;OLIVEIRA et al, 2012).…”

Section: Considerando a Falta De Estudos Sobre Lesões Nos óRgãos Genimentioning

confidence: 99%

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Correlation between chronic inflammation, immunostaining and parasite load in the genital system of female dogs naturally infected with Leishmania infantum

et al. 2016

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The aim of the present study was to investigate the correlations among chronic inflammatory reaction, immunostaining and parasite load in the genital system of female dogs naturally infected with Leishmania infantum . Animals (n = 10) used in this study were from the Department of Vector Control and Animal Surveillance of the municipality of Caruaru, state of Pernambuco, Brazil. Fragments of the vulva, vagina, cervix, uterine body, uterine horns and ovaries were submitted to histopathological analysis, immunohistochemistry (IHC) and DNA detection of amastigotes by qPCR. Correlations were found between the IHC findings and chronic inflammatory infiltrate related to L. Infantum only in the vulva and vagina; whereas, the same inflammatory reactions without immunostaining were observed in all organs, except the ovaries. L. Infantum DNA was detected in all organs of genital system, with no difference in parasite load observed among the different organs. No correlation was reported between parasite load and inflammatory lesions in the organs evaluated, except for the uterine body, in which an inverse correlation was detected. In conclusion, the vulva and vagina were the major sites of lesions and immunostaining for L. Infantum amastigotes in the genital system of female dogs. Moreover, parasite load exerted no influence on the intensity of the lesions in the organs evaluated.

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Parasitic Diseases

Weese

Peregrine

Anderson

et al. 2010

Companion Animal Zoonoses

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Companion animals can harbor a wide range of parasites, some of which are transmissible to humans. The overall burden of human diseases attributable to companion animal -associated parasites is unknown and varies greatly between regions. The risks associated with some are often overstated while others are largely ignored, and the range of illness can extend from mild and selflimited to fatal. Ascaris l umbricoides Companion Animal ZoonosesEdited by J. S. Weese and M. B. Fulford

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Transplacental Transmission of a North American Isolate of Leishmania infantum in an Experimentally Infected Beagle

Cited by 122 publications

References 25 publications

Canine Visceral Leishmaniasis, United States and Canada, 2000–2003

Canine Visceral Leishmaniasis, United States and Canada, 2000–2003

Correlation between chronic inflammation, immunostaining and parasite load in the genital system of female dogs naturally infected with Leishmania infantum

Parasitic Diseases

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