2021
DOI: 10.1016/j.isci.2021.103531
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Abstract: Summary Few studies have explored the association between SNPs and alterations in mRNA translation potential. We developed an approach to identify SNPs that can mark allele-specific protein expression levels and could represent sources of inter-individual variation in disease risk. Using MCF7 cells under different treatments, we performed polysomal profiling followed by RNA sequencing of total or polysome-associated mRNA fractions and designed a computational approach to identify SNPs showing a sign… Show more

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Cited by 1 publication
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References 68 publications
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“…The recent SNP2TFBS tool ( 7 ), for example, characterizes only around 3 million SNPs and uses only Jaspar database ( 22 ). Of note, provided that variants in UTRs can alter mRNA translation potential ( 41 ) also RBP consensus motifs were included to characterize UTR variants. In addition, our functional characterization in terms of regulatory elements uses our recent CONREL tool ( 18 ), exploiting hence a novel tissue level functional annotation of variants.…”
Section: Discussionmentioning
confidence: 99%
“…The recent SNP2TFBS tool ( 7 ), for example, characterizes only around 3 million SNPs and uses only Jaspar database ( 22 ). Of note, provided that variants in UTRs can alter mRNA translation potential ( 41 ) also RBP consensus motifs were included to characterize UTR variants. In addition, our functional characterization in terms of regulatory elements uses our recent CONREL tool ( 18 ), exploiting hence a novel tissue level functional annotation of variants.…”
Section: Discussionmentioning
confidence: 99%