2017
DOI: 10.1111/acel.12628
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Abstract: SummaryWhether errors in protein synthesis play a role in aging has been a subject of intense debate. It has been suggested that rare mistakes in protein synthesis in young organisms may result in errors in the protein synthesis machinery, eventually leading to an increasing cascade of errors as organisms age. Studies that followed generally failed to identify a dramatic increase in translation errors with aging. However, whether translation fidelity plays a role in aging remained an open question. To address … Show more

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Cited by 55 publications
(51 citation statements)
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“…Later, Ke et al. extended these findings using comparative approach and showed that translational fidelity appears to positively correlate with lifespan across 17 different rodent species . It is difficult to prove that the cleavage of the 28s rRNA causes the increase in translational fidelity because reconstitution of a purified NMR ribosome has not yet been reported.…”
Section: Proteomics and The Hallmarks Of Agingmentioning
confidence: 99%
“…Later, Ke et al. extended these findings using comparative approach and showed that translational fidelity appears to positively correlate with lifespan across 17 different rodent species . It is difficult to prove that the cleavage of the 28s rRNA causes the increase in translational fidelity because reconstitution of a purified NMR ribosome has not yet been reported.…”
Section: Proteomics and The Hallmarks Of Agingmentioning
confidence: 99%
“…Several lines of evidence suggest that physiological gene expression accuracy has evolved to a point where error levels are just low enough to avoid interfering with biological processes. Relevant observations include the apparent co-evolution of longevity and translational accuracy in mammals 13 , and the evolutionary selection for less error-prone codons at structurally sensitive sites in proteins 14 . Moreover, several studies observed apparent regulation of amino acid misincorporation levels by cellular signalling pathways 7,15,16 .…”
Section: Gst-dissc Gst-optscmentioning
confidence: 99%
“…This improved translational fidelity may result from a unique ribosomal structure where 28S ribosomal RNA is cleaved into two smaller fragments. Furthermore, translational fidelity correlates positively with MLS across multiple species of rodents [93]. More accurate protein synthesis may contribute to longevity of long-lived species by reducing the number of misfolded proteins that accumulate over time.…”
Section: Proteostasis Networkmentioning
confidence: 99%