Translation: Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7)

He, Yueyue

doi:10.1097/im9.0000000000000022

Cited by 19 publications

(9 citation statements)

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“…Oropharyngeal and nasal swab samples were taken from all patients upon hospital admission [12]. A positive result of real time reverse transcriptase polymerase chain reaction of swabs was defined as a confirmed COVID-19 case [13]. For polymerase chain reaction (PCR) negative COVID-19 patients, chest computed tomography (CT) is a sensitive diagnostic approach in the early term and recommended for faster triage of those patients.…”

Section: Study Design and Participantsmentioning

confidence: 99%

An easy-to-use nomogram for predicting in-hospital mortality risk in COVID-19: a retrospective cohort study in a university hospital

et al. 2021

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Background One-fifth of COVID-19 patients are seriously and critically ill cases and have a worse prognosis than non-severe cases. Although there is no specific treatment available for COVID-19, early recognition and supportive treatment may reduce the mortality. The aim of this study is to develop a functional nomogram that can be used by clinicians to estimate the risk of in-hospital mortality in patients hospitalized and treated for COVID-19 disease, and to compare the accuracy of model predictions with previous nomograms. Methods This retrospective study enrolled 709 patients who were over 18 years old and received inpatient treatment for COVID-19 disease. Multivariable Logistic Regression analysis was performed to assess the possible predictors of a fatal outcome. A nomogram was developed with the possible predictors and total point were calculated. Results Of the 709 patients treated for COVID-19, 75 (11%) died and 634 survived. The elder age, certain comorbidities (cancer, heart failure, chronic renal failure), dyspnea, lower levels of oxygen saturation and hematocrit, higher levels of C-reactive protein, aspartate aminotransferase and ferritin were independent risk factors for mortality. The prediction ability of total points was excellent (Area Under Curve = 0.922). Conclusions The nomogram developed in this study can be used by clinicians as a practical and effective tool in mortality risk estimation. So that with early diagnosis and intervention mortality in COVID-19 patients may be reduced.

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Section: Study Design and Participantsmentioning

confidence: 99%

An easy-to-use nomogram for predicting in-hospital mortality risk in COVID-19: a retrospective cohort study in a university hospital

et al. 2021

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“…Nonetheless, the risks and benefits of glucocorticoid adjuvant therapy for COVID-19 are inconclusive. The WHO's 2019-nCoV-related severe infection clinical guidelines [9] and a review article in Lancet [10] do not recommend the use of glucocorticoids in the treatment of patients with COVID-19, but Chinese experts and scholars believe that the early application of hormones is really helpful for alleviating the condition of patients [11] .…”

Section: Introductionmentioning

confidence: 99%

Effect of methylprednisolone in severe and critical COVID-19: Analysis of 102 cases

Zhu¹,

Li²,

Li³

et al. 2020

WJCC

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Author contributions: Zhu HM wrote the paper; Zhang M designed the research; Li Y and Yang S performed the research; Peng D and Yang X performed data and statistical analyses; Peng D and Li BY analyzed the data; Sun XL collected the data. Institutional review board statement: This survey was a retrospective study collecting only the clinical data of patients. Since it did not bring risks to patients' physiology and did not interfere with patients' treatment plan, and researchers protected patients' information from disclosure, Xuanwu Hospital of Capital Medical University agreed to exempt this study from ethical review. Informed consent statement:The need for individual consent was waived by the committee.

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“…The convalescent patients were defined as those who have met the criteria of medical isolation and discharge [ 3 ]. The criteria was: (1) body temperature returned to normal for more than three days; (2) respiratory symptoms improved significantly; (3) lung imaging showed obvious absorption; (4) two consecutive negative test results of nucleic acid (the sampling interval was at least one day) [ 2 ].…”

Section: Methodsmentioning

confidence: 99%

“…The coronavirus disease 2019 (COVID-19) pandemic is still severe all around the world, with over 472 million cases and 6 million deaths cumulatively reported by World Health Organization till March 24, 2022 [ 1 ]. In China, traditional Chinese medicine (TCM) together with Western medicine has been highly recommended in prevention, and treatment of COVID-19 [ 2 , 3 ]. TCM has played an important role in relieving symptoms of COVID-19 patients as well as delaying or reducing the progression from mild to severe condition [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Till January 17, 2022, almost 123,169 COVID-19 patients have been cured and discharged from hospitals in China [ 6 ]. For convalescent patients, who had met the discharge criteria (absence of clinical symptoms and radiological abnormalities, as well as two consecutive negative test results of real time reverse transcriptase-polymerase chain reaction (RT-PCR)) [ 2 ], about 10% patients may still experience mild clinical discomforts such as cough and fatigue, especially those who were severe or critical cases [ 4 , 7 , 8 ]. As the number of patients who are discharged from hospitals or discontinued of quarantine has increased rapidly, the management of convalescent COVID-19 patients has gradually become a new urgency [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Ludangshen oral liquid for treatment of convalescent COVID-19 patients: a randomized, double-blind, placebo-controlled multicenter trial

Peng

Huang

et al. 2022

Chin Med

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Objective To explore the effect of Ludangshen oral liquid for treatment of convalescent patients with coronavirus disease 2019 (COVID-19) with randomized, double-blind, placebo-controlled multicenter method. Methods 200 convalescent COVID-19 patients who had symptoms related to decreased digestive and respiratory function were randomly divided to either receive Ludangshen oral liquid or placebo for 2 weeks. The severity of clinical symptoms including fatigue, anorexia, abdominal distension, loose stools, and shortness of breath were assessed by visual analogue scale and observed at before and after treatment. The improvement and resolution rates of clinical symptoms were evaluated. Full analysis set (FAS) and per-protocol set (PPS) were used for statistical analyses. Adverse events were recorded during the study. Results 8 patients did not complete the study. After 2 weeks of treatment, both FAS and PPS results showed that patients in Ludangshen group had significantly lower score of fatigue, anorexia, loose stools, and shortness of breath than placebo group (P < 0.05), while there was no significant difference in distention (P > 0.05). The improvement rate of fatigue, anorexia, distension, loose stools and shortness of breath were significantly higher in Ludangshen group (P < 0.05), as well as the resolution rates (P < 0.05) except for shortness of breath (P > 0.05). There were two cases of adverse events, with one nose bleeding in Ludangshen group and one headache in placebo group. Conclusion The study suggested that two weeks of Ludangshen oral liquid treatment may have certain effects for convalescent COVID-19 patients on improving digestive and respiratory symptoms including fatigue, anorexia, loose stools and shortness of breath, which may be one of the choices for management of convalescent COVID-19 patients with digestive and respiratory symptoms.

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Translation: Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7)

Cited by 19 publications

References 0 publications

An easy-to-use nomogram for predicting in-hospital mortality risk in COVID-19: a retrospective cohort study in a university hospital

An easy-to-use nomogram for predicting in-hospital mortality risk in COVID-19: a retrospective cohort study in a university hospital

Effect of methylprednisolone in severe and critical COVID-19: Analysis of 102 cases

Ludangshen oral liquid for treatment of convalescent COVID-19 patients: a randomized, double-blind, placebo-controlled multicenter trial

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