“…Pain is the main symptom leading patients to seek medical care, and chronic pain is one of the main sources of “years of lived with disability”, representing an enormous economic burden to health care systems [ 1 , 2 , 3 , 4 ]. More than 30% of the world’s population suffers from chronic pain [ 2 , 5 , 6 , 7 , 8 ]. Chronic pain lacks the protective function of acute pain and may be caused by several conditions, such as long-term inflammatory events, traumatic and metabolic injuries of the nervous system, and diseases or their treatment, such as cancer and chemotherapy [ 1 , 2 , 4 ].…”