Translation, adaptation and validation of two versions of the Chronic Liver Disease Questionnaire in Malaysian patients for speakers of both English and Malay languages: a cross-sectional study

Khairullah, Shasha; Mahadeva, Sanjiv

doi:10.1136/bmjopen-2016-013873

Cited by 8 publications

(9 citation statements)

References 23 publications

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“…This observation strongly supports the construct validity of the CLDQ‐SG for the assessment of severity of liver disease in the different groups of CLD patients. Our findings are consistent with similar studies of translation and validation of the CLDQ in various ethnic populations . Clinicians can thus rely on the CLDQ‐SG to assess the deterioration of HRQOL as CLD progresses.…”

Section: Discussionsupporting

confidence: 90%

“…The predominant etiology of CLD was chronic hepatitis B, which accounted for 78.9% of cases, in keeping with the expected etiological spectrum in the Singapore population . The median duration of CLD was 9 years from the date of first diagnosis, with a range of 5–17 years.…”

Section: Resultssupporting

confidence: 63%

“…The Chronic Liver Disease Questionnaire (CLDQ) is the most widely validated disease‐specific HRQOL instrument developed for patients with CLD . The CLDQ has been cross‐culturally validated and translated into several different languages worldwide and has demonstrated excellent validity and reliability for the assessment of HRQOL in CLD irrespective of language, cultural differences, educational level, and etiology of liver disease . Despite this, measurement of HRQOL is not commonly performed in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Clinical validation of the chronic liver disease questionnaire for the Chinese population in Singapore

et al. 2019

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Background and Aim Assessment of health‐related quality‐of‐life (HRQOL) in patients with chronic liver disease (CLD) requires the use of validated instruments that are understood by patients in their native language. We previously translated the Chronic Liver Disease Questionnaire into the Singapore‐Mandarin version (CLDQ‐SG). This study aims to examine the internal consistency and validity of the CLDQ‐SG in patients with CLD. Methods We conducted a cross‐sectional study of adult patients with CLD seen in a tertiary center in Singapore who completed both the CLDQ‐SG and Short Form Health Survey 36 version 2 (SF‐36v2) questionnaires. Internal consistency of the CLDQ‐SG was assessed using Cronbach's alpha coefficient. Convergent and divergent validity of the SF‐36v2 was assessed using the Spearman correlation coefficient, while discriminant validity was assessed using the Jonckheere‐Terpstra test for trend. Exploratory factor analysis was performed to evaluate the factor structure of the CLDQ‐SG. Results We enrolled 242 subjects (68.2% males, median age 67 years). Predominant etiology of CLD was chronic hepatitis B. Severity of CLD was divided into noncirrhotic (67.3%), compensated cirrhosis (24.0%), and decompensated cirrhosis (8.7%). Item convergent and discriminant validity of the CLDQ‐SG was excellent, with 100% scaling success in all six domains. All domains exhibited good internal consistency, with Cronbach's α > 0.70. We observed a consistent trend of a reduction in mean CLDQ‐SG score in the three groups reflecting the discriminant validity of the CLDQ‐SG to assess changes in HRQOL in different severities of CLD. Factor analysis of the CLDQ‐SG demonstrated an independent factor assessing sleep. Conclusion The Singapore‐Mandarin version of CLDQ‐SG is a valid and reliable instrument to measure HRQOL in patients with CLD.

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Section: Discussionsupporting

confidence: 90%

Section: Resultssupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

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Clinical validation of the chronic liver disease questionnaire for the Chinese population in Singapore

et al. 2019

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“…Janani et al 31 reported that SF-36 and CLDQ scores were lower in cirrhosis patients with Child-Turcotte-Pugh class C, and CLDQ score was lower in younger patients (≤45 years). Khairullah & Mahadeva 32 reported that CLDQ scores were significantly lower for patients with decompensated cirrhosis compared to compensated or no cirrhosis. In this study, there were differences in SNAC total scores according to disease stage and patient's age which supports known group validity.…”

Section: Discussionmentioning

confidence: 99%

<p>Development and Evaluation of the Supportive Needs Assessment Tool for Cirrhosis (SNAC)</p>

Valery¹,

Bernardes²,

Stuart³

et al. 2020

PPA

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Background: We report the development and psychometric testing of a Supportive Needs Assessment tool for Cirrhosis (SNAC). Methods: The 50-item SNAC was administered to patients (n=465) diagnosed with cirrhosis recruited from five metropolitan hospitals in Queensland, Australia. Items were assessed for ceiling and floor effects, and exploratory factor analysis was used to assess the factor structure. Identified factors were assessed for internal consistency and convergent validity to validated psychosocial tools. Results: Exploratory factor analysis identified 4 factors (39 items), which together accounted for 49.2% of the total variance. The 39-item SNAC met the requirements of a needs assessment tool and identified a range of needs important to patients with cirrhosis that were grouped in four subscales: "Psychosocial issues", "Practical and physical needs", "Information needs", and "Lifestyle changes". Cronbach's alpha values for the four subscales ranged from 0.64 to 0.92. Convergent validity was supported by a strong correlation between the total SNAC score and that of the Chronic Liver Disease Questionnaire (CLDQ; Spearman rho −0.68; p<0.001), and moderate correlations with the Distress Thermometer (Spearman rho 0.53; p<0.001) and seven subscales of a generic health-related quality of life instrument (Short Form 36; Spearman rho ranged from −0.48 to −0.57; p<0.001). The SNAC discriminated patient groups with respect to sex (p=0.013), age group (p<0.001), and hospital admission status (admitted vs not; p<0.001). Conclusion: These data provide initial evidence for the validity and reliability of the SNAC, an instrument designed to measure type and amount of perceived unmet practical and psychological needs of people diagnosed with cirrhosis.

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“…Chronic Liver Disease Questionnaire (CLDQ) as a useful PRO for measuring HRQOL in patients with CLD 8 . CLDQ is known to correlate with liver reserve function such as Child‐Pugh classification, and its usefulness and reliability to assess HRQOL in patients with CLD have been confirmed in various ethnicities, liver disease etiologies, regions and countries around the world, 9–14 including in Japanese patients 15,16 . It involves 29 questions categorized into six domains, abdominal symptoms (AS), fatigue (FA), emotional functions, worry (WO), activity (AC), and systemic symptoms (SS).…”

Section: Introductionmentioning

confidence: 99%

Chronic liver disease questionnaire to manage patients with chronic liver diseases

Tajiri

Futsukaichi

Murayama

et al. 2022

Hepatology Research

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Background and Aims Although patients with chronic liver disease (CLD) usually show few symptoms, they exhibit decreased health‐related QOL (HRQOL) with occurrence complications including hepatocellular carcinoma (HCC). Health‐related QOL is an important indicator in the management of CLD. The Chronic Liver Disease Questionnaire (CLDQ) was established as a tool for assessment of HRQOL. In this study, we evaluate its usefulness for the management of daily clinical practice. Methods Patients (N = 190, median age 70 years old) treated between 2016 and 2019 were registered and prospectively followed‐up with annual CLDQ. Associations of liver function and development of factors for admission or death were evaluated. Results Of the 190 patients registered, median age 70 years old, 140 were Child‐A, 121 were Fib‐4 index >2.67 and showed 80 HCC. All 6 domains including Systemic Symptoms (SS) were negatively correlated with Child‐Pugh score more than with albumin‐bilirubin score and Fib‐4 index. A hundred four admission events and 49 deaths were found during observation period, and median event‐free survival was 34.3 months. Treatment for HCC was the most frequent cause of admission, and 37 liver‐related deaths were found. Systemic Symptoms score 2 years after registration was decreased in both HCC‐ and non‐HCC cohort. Systemic Symptoms decreased and SS < 4 might be predictive for event occurrence. Conclusions CLDQ is useful to assess HRQOL in patients with CLD and is well correlated with liver function especially Child‐Pugh. Chronic Liver Disease Questionnaire might be useful to predict the prognosis of CLD and can be a tool of management in clinical practice.

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Translation, adaptation and validation of two versions of the Chronic Liver Disease Questionnaire in Malaysian patients for speakers of both English and Malay languages: a cross-sectional study

Cited by 8 publications

References 23 publications

Clinical validation of the chronic liver disease questionnaire for the Chinese population in Singapore

Clinical validation of the chronic liver disease questionnaire for the Chinese population in Singapore

<p>Development and Evaluation of the Supportive Needs Assessment Tool for Cirrhosis (SNAC)</p>

Chronic liver disease questionnaire to manage patients with chronic liver diseases

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