[Translated article] Vismodegib and Sonidegib in Locally Advanced and Metastatic Basal Cell Carcinoma: Update on Hedgehog Pathway Inhibitors

Wijaya, Juwina; Djawad, Khairuddin; Wahab, Siswanto; Sumarheni, Sumarheni; Anwar, A. Irawan

doi:10.1016/j.ad.2022.04.003

Cited by 1 publication

(1 citation statement)

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“…Radiotherapy and electrochemotherapy are used as an alternative therapy to surgery in complex areas such as the face, in elderly patients with comorbidities or in recurrent BCC 9,10 . Hedgehog inhibitors (vismodegib and sonidegib) have shown good results in locally advanced and metastatic BCC 11 , 12 . Recently, cemiplimab (programmed death receptor 1 inhibitor) was approved as a second treatment option in resistant cases 13 .…”

Section: Introductionmentioning

confidence: 99%

Non‐invasive imaging techniques in presurgical margin assessment of basal cell carcinoma: Current evidence

Janowska

Oranges

Granieri

et al. 2023

Skin Research and Technology

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Background:The diagnosis of basal cell carcinoma (BCC) is based on clinical and dermoscopical features. In uncertain cases, innovative imaging techniques, such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT), have been used. The main limitation of these techniques is the inability to study deep margins. HFUS (high-frequency ultrasound) and the most recent UHFUS (ultra-highfrequency ultrasound) have been used in various applications in dermatology, but theyare not yet routinely used in the diagnosis of BCC. A key point in clinical practice is to find an imaging technique that can help to reduce post-surgical recurrences with a careful presurgical assessment of the lesional margins. This technique should show high sensitivity, specificity, reproducibility and simplicity of execution. This concept is very important for the optimal management of patients who are often elderly and have many comorbidities. The aim of the paper is to analyse the characteristics of current imaging techniques and the studies in the literature on this topic. Materials and methods:The authors independently searched the MEDLINE, PubMed, Embase, Scopus, ScienceDirect and Cochrane Library databases for studies looking for non-invasive imaging techniques for the presurgical margin assessment of BCC.Results: Preoperative study of the BCC subtype can help to obtain a complete excision with free margins. Different non-invasive imaging techniques have been studied for in vivo evaluation of tumour margins, comparing the histologic evaluation with a radical surgery. The possibility to study the lateral and deep margins would allow a reduction of recurrences and sparing of healthy tissue. Conclusion: HFUS and UHFUS represent the most promising, non-invasive techniquesfor the pre-operative study of BCC facilitating the characterization of vascularization, deep lateral margins and high-risk subtypes, although they are limited by insufficient literature unlike RCM and OCT.

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