Transition-Metal-Free C–H Trifluoromethylthiolation of N,N-Disubstituted Enaminones To Access CF3S-Functionalized Enaminones and Their Application in the Synthesis of CF3S-Heteroaryls
Jinbiao Ying,
Tao Zhou,
Yunyun Liu
et al.
Abstract:The α-C–H trifluoromethylthiolation of N,N-disubstituted enaminones has been achieved with simple
and cheap
CF3SO2Na as the CF3S source. The
reactions were run at mild temperature (0 °C to rt) using POCl3 as the only reducing reagent. The work represents the first
example on the synthesis of α-trifluoromethylthio
enaminones via direct C–H functionalization. In addition, the
resulting CF3S-functionalized enaminones have been proven
as useful building blocks in the synthesis of various CF3S-functionalized hetero… Show more
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