Current Opinion in Lipidology volume 29, issue 1, P10-17 2018 DOI: 10.1097/mol.0000000000000473 View full text
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Laurens F. Reeskamp, Emma C.E. Meessen, Albert K. Groen

Abstract: TICE contributes significantly to FNS excretion in humans, independently of the biliary pathway. Knowledge about its underlying cellular mechanisms surges through in-vivo and in-vitro studies in mice and humans. TICE might be an interesting therapeutic target for increasing cholesterol disposal with the feces. Albeit multiple therapeutic options are available, studies showing clinical benefit are still needed.