1990
DOI: 10.1083/jcb.110.1.43
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Abstract: Abstract. Human neutrophils exhibit multiple increases in cytosolic free calcium concentration ([Ca2+]3 spontaneously and in response to the chemoattractant N-formyl-L-methionyl-L-leucyl-Lphenylalanine (Jaconi, M. E. E., R. W. Rivest, W. Schlegel, C. B. Wollheim, D. Pittet, and P. D. Lew. 1988. J. Biol. Chem. 263:10557-10560). The function of these repetitive increases in [Ca2+]~, as well as the role of Ca 2+ in human neutrophil migration, remain unresolved. We have used microspectrofluorometry to measure [Ca… Show more

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Cited by 243 publications
(120 citation statements)
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“…2c) at 490 nm. We have also confirmed the presence of Ca 2ϩ spikes in polarized neutrophils (15) using quantitative microfluorometry at ϳ415 nm ( Fig. 2d) and 490 nm (Fig.…”
Section: Spectral Characterization Of System Performancesupporting
confidence: 50%
See 3 more Smart Citations
“…2c) at 490 nm. We have also confirmed the presence of Ca 2ϩ spikes in polarized neutrophils (15) using quantitative microfluorometry at ϳ415 nm ( Fig. 2d) and 490 nm (Fig.…”
Section: Spectral Characterization Of System Performancesupporting
confidence: 50%
“…To test the effect of shutter speed on images, the CCD chip was electronically gated for various times. Polarized neutrophils display repetitive Ca 2ϩ spikes (15,33). Fig.…”
Section: Temporal Characterization Of Ca 2ϩ Signal Detectionmentioning
confidence: 99%
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“…Our model suggests that the intracellular Ca 2+ network plays a key role in generating the internal motor for cell locomotion. Indeed, given that Ca 2+ concentration alterations, observed in migrating cells, 63,64 can be a key factor in FA disassembly, 65,66 as well as the finding that lamellae formation is inversely proportional to cAMP concentration, 67 it seems reasonable to propose the direct involvement of both the Ca 2+ and cAMP networks in migration via the lamella protrusion and retraction mechanisms.…”
Section: Discussionmentioning
confidence: 99%