Transient Aplastic Crisis in Patients With Sickle Cell Disease

Epidemiology of human parvovirus B19 in children with sickle cell disease

“…The point prevalence rate at entry in this study, 29.8%, is similar to a Jamaican report involving a cohort of children with SCD-SS (37%) and a small cohort of children with SCD followed in Brooklyn, New York (34.5%). 2,20 Yet both the point prevalence rate and the period prevalence rate in this study (47%) are lower than the infection rate reported in a second Jamaican cohort, 63%. 3 The differences between the prevalence rates in this and the Jamaican reports may be explained by differences in the median age of the subjects at the time of initial and final serologic testing, differences in the percentage of patients who were HPV B19 positive at study entry, and differences in HPV B19 epidemic frequencies in Jamaica and the northeastern United States.…”

Prevalence and incidence of erythrovirus B19 infection in children with sickle cell disease: The impact of viral infection in acute clinical events

“…The estimated B19V prevalence was 29.5%, similar to that found (29.8%) in 633 pediatric patients with sickle cell anemia from Philadelphia, USA [Smith‐Whitley et al, ]. Higher prevalence rates of B19V infection were observed in a small cohort of children with sickle cell anemia from New York, USA (34.5%) [Rao et al, ], and Jamaica (37%) [Serjeant et al, ]. Another study [Regaya et al, ] conducted in Tunisian patients with sickle cell disease or other hemoglobinopathies showed a much higher (56.5%) B19V prevalence.…”

“…The morbidity of B19V infection in children with sickle cell anemia was evident because of its association with transient aplastic crisis, acute splenic sequestration, and higher frequency of hospitalization and transfusion procedures. The association of B19V with transient aplastic crisis is well known in the literature [Serjeant et al, ; Anderson et al, ; Rao et al, ]. In this study, 24% of 33 children with current/recent infection had episodes of transient aplastic crisis.…”

Human Parvovirus B19 May Be a Risk Factor in Myasthenia Gravis with Thymoma

“…In fact, this phenomenon was noted not only in studies of B19V but also in those of other viruses, especially hepatitis B virus. 32 - 37 Thus, more research is required to elucidate this phenomenon.…”