Transient Acantholytic Dermatosis with Involvement of Oral Mucosa

Abstract

Histologic, immunologic and electron microscopic studies were performed in a patient with transient acantholytic dermatosis which involved oral mucosa. Hitologic and electron microscopic findings were almost identical in both cutaneous and mucous membrane lesions, and these were similar to pemphigus vulgaris; suprabasilar separation with acantholytic cells. Desmosome-desmosome complexes were separated without disruption of cell membranes and cytoplasmic structures were well-preserved without dyskeratosis. Lamina lucida, however, was often separated in mucous membrane lesions, in contrast to the normal lamina lucida in cutaneous lesions of such cases or in pemphigus vulgaris. Direct and indirect immunofluorescence studies for pemphigus were repeatedly negative. This study shows that transient acantholytic dermatosis may involve mucous membrane and may resemble pemphigus vulgaris histologically and ultrastructurally except for the widened lamina lucida of the mucous membrane.

Successful Treatment of Transient Acantholytic Dermatosis with Systemic Steroids

“…In the TAD group, the papulovesicular form was named "classic Grover's disease" and the other types be came "TAD variants". The forms of TAD variants are bullous (15)(16)(17), papular (10), The etiology and pathogenesis of the dis ease is unknown. Several factors may play roles in triggering the disease (Fig.…”

Klinische Merkmale und Behandlungen der transitorischen akantholytischen Dermatose (Morbus Grover): ein systematischer Review

“…Kortikosteroide und Calcineurininhibitoren), systemische Wirkstoffe (Antibiotika und Immunsuppressiva), physikalische Therapien, Phototherapie und Strahlentherapie bewertet. Die Schleimhäute blieben in der Regel verschont, einige Fälle mit Schleimhautbeteiligung wurden jedoch berichtet (9, 3 %) [13,14]. Auffällige Verteilungsmuster der Läsionen, die sich von den klassischen diskreten, vereinzelten Läsionen unterschieden, waren der lineare (1 %), der blaschkoide und der zosteriforme (1 %) Typ [15,16].…”

Effective Treatment of Persistent Grover's Disease with Trichloroacetic Acid Peeling

“…7 Many diverse morphologies have been reported, however (Table 1). 2,[8][9][10][11][12][13][14][15] Although the pathogenesis remains unknown, it can be exacerbated in response to excessive heat, sweating, ionizing radiation, 12,16 or even xerosis (Table 2). 7,17 Rarely, medications have been shown to play a causative role.…”