Transient acantholytic dermatosis

Grover, Ralph W.

doi:10.1001/archderm.101.4.426

Cited by 49 publications

(12 citation statements)

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“…Acantholytic changes may be seen in numerous and heterogeneous clinical conditions: (i) genodermatoses (Hailey-Hailey disease, Darier disease); (ii) infections; (iii) pemphigus; (iv) several malignant or premalignant conditions (acantholytic type of solar keratosis, in which one observes immediately above the atypical cells composing the basal cell layer clefts or lacunae similar to those seen in Darier disease [8]or in Paget disease [9]); (v) Grover disease [10, 11, 12]. …”

Section: Discussionmentioning

confidence: 99%

In vivo Enalapril-Induced Acantholysis

Schiavo

Guerrera²,

Cozzani³

et al. 1999

Dermatology

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Enalapril is a widely used antihypertensive drug with a very powerful in vitro acantholytic effect. It has been known to potentially induce pemphigus in genetically predisposed subjects. The action mechanism is complex and still only partially understood. We describe the case of a 66-year-old man, affected with intermediary basal cell carcinoma, in whom the histological examination showed suprabasal acantholytic clefts in the perilesional epidermis. Surprisingly a second biopsy taken from the apparently healthy skin of his back confirmed the presence of acantholytic changes. Clinical signs of pemphigus were absent. The patient’s history did not reveal any relevant data but a mild arterial hypertension that had been treated for 1 year with 10 mg enalapril. Taking into account the patient’s history (enalapril long-term administration), the absence of any bullous or erosive lesions and the histological findings, a diagnosis was made of in vivo enalapril-induced acantholysis.

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Section: Discussionmentioning

confidence: 99%

In vivo Enalapril-Induced Acantholysis

Schiavo

Guerrera²,

Cozzani³

et al. 1999

Dermatology

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“…Patients develop pruriginous skin papules, papulovesicles, and small nodules, mainly on the chest, back, lumbar area, and extremities [2, 3]. The histological diagnosis of clinically suspected lesions may be compromised by GD's capacity to adopt differing patterns, and by the fact that involved areas are generally diagnosed as focal.…”

Section: Introductionmentioning

confidence: 99%

Grover's Disease after Heart Transplantation: A Case Report

Ippoliti

Paulli

Lucioni

et al. 2012

Case Reports in Transplantation

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Grover's disease is a transient acantholytic dermatosis of unknown cause, manifesting clinically as a papular skin eruption that is usually located on the anterior chest and abdomen. Histologically characterized by an acantholytic pattern, it has been associated with numerous disorders, including hematologic malignancies, chronic renal failure, and HIV infection, as well as with chemotherapy and bone marrow and/or kidney transplant. Evaluation of followup and treatment is often complicated by spontaneous remission and the occasionally fluctuant course of the disease. Here we report the case of a patient with sudden onset of Grover's disease after heart transplantation. To the best of our knowledge, this is the first observation of Grover's disease as diagnosed after heart transplantation.

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“…Sie ist durch einen mit Pruritus verbundenen papulovesikulären Ausschlag am Oberkörper gekennzeichnet [15]. In der Regel klingt sie nach einigen Wochen bis Monaten spontan wieder ab.…”

Section: Definition Und Klinische Merkmaleunclassified

Management von paraneoplastischem Pruritus

Rowe¹,

Yosipovitch²

2018

Kompass Dermatol

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Paraneoplastischer Pruritus tritt als systemische Reaktion auf eine zugrunde liegende maligne Erkrankung auf. Paraneoplastischer Pruritus ist am häufigsten mit malignen lymphoproliferativen Erkrankungen sowie soliden Tumoren, die zu Cholestase führen, assoziiert. Paraneoplastischer Pruritus kann sich sowohl ohne primären Hautausschlag manifestieren als auch in Verbindung mit dermatologischen Erkrankungen wie Erythrodermie, Acanthosis nigricans, Dermatomyositis (DM), transitorischer akantholytischer Dermatose (Morbus Grover) oder eruptiver seborrhoischer Keratose. Die Behandlung des paraneoplastischen Pruritus beruht primär auf der Behandlung der zugrunde liegenden malignen Erkrankung, die ursächlich für die systemische Reaktion ist. Wenn die maligne Erkrankung nicht auf Behandlung anspricht, können andere Therapien beim paraneoplastischen Pruritus wirksam sein, wie selektive Serotonin-Wiederaufnahmehemmer, Mirtazapin, Gabapentin, Thalidomid, Opioide, Aprepitant und Histon-Deacetylase-Inhibitoren. Übersetzung aus Curr Probl Dermatol. Basel, Karger, 2016, vol 50, pp 149-154 (DOI: 10.1159/000446060)

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Transient acantholytic dermatosis

Cited by 49 publications

References 0 publications

In vivo Enalapril-Induced Acantholysis

In vivo Enalapril-Induced Acantholysis

Grover's Disease after Heart Transplantation: A Case Report

Management von paraneoplastischem Pruritus

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