J. Neurosci. Res. volume 86, issue 9, P2111-2124 2008 DOI: 10.1002/jnr.21645 View full text
Martha E. Stokely, Puja Garg, Manzoor A. Bhat, Peter Koulen

Abstract: Discovery of treatments to protect axonal function of neurons and prevent permanent disability associated with progressive multiple sclerosis (MS) has faced the uphill challenge of assessing relatively small changes in accumulated axon damage within a background environment that is disorganized by CNS inflammation. We hypothesized that transient immunosuppression after initiation of MS-like autoimmune mechanisms would disassociate development of MS-like myelinated axon pathology from development of CNS inflamm…

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