2016
DOI: 10.18632/aging.101060
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Abstract: Cyclooxygenase (COX) is a key enzyme in the biosynthesis of prostanoids, lipid signaling molecules that regulate various physiological processes. COX2, one of the isoforms of COX, is highly inducible in response to a wide variety of cellular and environmental stresses. Increased COX2 expression is thought to play a role in the pathogenesis of many age-related diseases. COX2 expression is also reported to be increased in the tissues of aged humans and mice, which suggests the involvement of COX2 in the aging pr… Show more

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Cited by 23 publications
(22 citation statements)
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References 68 publications
(57 reference statements)
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“…Furthermore, the knockdown of TRPC7 inhibited UVB‐induced p53 expression in keratinocytes (Figure e–g), which was corroborated by our observation that the UVB‐induced activation of the p53 pathway was reduced in TRPC7 +/− and TRPC7 −/− mice (Figure i). In addition, extracellular Ca 2+ influx is known to induce cyclooxygenase‐2 (COX‐2) expression, which increases p53 pathway activation and promotes the aging process (Hsu et al, ; Kim et al, ). We found that after UVB exposure, the high levels of COX‐2 protein expression observed in the epidermis of wild‐type mice were decreased to minimal levels in TRPC7 +/− and TRPC7 −/− mice (Figure h).…”
Section: Resultsmentioning
confidence: 99%
“…Aspirin is thought to exert its effects through inhibition of COX enzymes . In addition, we previously have reported that the inducible, transgenic expression of COX2 causes accumulation of senescent cells and early aging phenotypes in adult mice . Therefore, we focused our investigation on the role of COX2 in DOX‐induced cellular senescence.…”
Section: Resultsmentioning
confidence: 99%
“…70 Finally, we recently have reported that inducible COX2 expression in adult mice promotes senescence and early aging. 30 We have previously reported that genetic deletion or pharmacological inhibition of COX2, but not COX1, suppresses DOX-induced accumulation of p53. 18 In addition, our current data show that aspirin suppresses DOX-induced p53 accumulation in normal human fibroblasts and WT MEFs.…”
Section: Discussionmentioning
confidence: 97%
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