2016
DOI: 10.18632/aging.100932
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Abstract: Accumulating evidence suggests that early-life diet may program one's health status by causing permanent alternations in specific organs, tissues, or metabolic or homeostatic pathways, and such programming effects may propagate across generations through heritable epigenetic modifications. However, it remains uninvestigated whether postnatal dietary changes may program longevity across generations. To address this question of important biological and public health implications, newly-born flies (F0) were colle… Show more

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Cited by 33 publications
(32 citation statements)
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References 68 publications
(105 reference statements)
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“…Virgin male flies were used, as longevity experiments would last a shorter time with males, and the transgenerational programming effects on longevity appear to be independent of gender, mating and reproduction after the LP PDM [12]. Newly-born F0 flies were subjected to a 7-day PDM with the LP diet.…”
Section: Resultsmentioning
confidence: 99%
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“…Virgin male flies were used, as longevity experiments would last a shorter time with males, and the transgenerational programming effects on longevity appear to be independent of gender, mating and reproduction after the LP PDM [12]. Newly-born F0 flies were subjected to a 7-day PDM with the LP diet.…”
Section: Resultsmentioning
confidence: 99%
“…Transgenerational inheritance of nutritional programming of metabolic status and longevity has been recently demonstrated in flies, supporting the use of this simple but genetically tractable system for studying the epigenetic inheritance of nutritional programming [11, 12]. Importantly, this model offers multiple advantages, in particular to identify and characterize the epigenetic mechanisms underlying nutritional programming of longevity across generations.…”
Section: Introductionmentioning
confidence: 99%
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“…Трансгенерационные эффекты в отношении ПЖ выявлены в недавнем исследовании, осуществлен-ном на плодовой мушке Drosophila melanogaster [36]. В этой работе мушек после вылупления из куколок содержали на пищевой смеси с различным соот-ношением белков и углеводов.…”
Section: плодовая мушкаunclassified