“…Similarly, Rosshart and colleagues showed SPF-type mice reconstituted with natural microbiota exhibited reduced inflammation and increased survival following influenza virus infection, and they showed improved resistance against colorectal tumorigenesis [ 13 , 14 ]. Finally, as discussed by Juffermans and colleagues, there are other reasons for why so few drugs translate from animals to humans, including poor clinical trial design, patient selection, and many other factors [ 1 ].…”