Transforming Growth Factor β in Retinoblastoma-Related Cataract

Kase, Satoru; Parikh, Jignesh; Youssef, Peter N.; Murphree, A. Linn; Rao, Narsing A.

doi:10.1001/archopht.126.11.1539

Cited by 12 publications

(9 citation statements)

References 9 publications

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“…A single injection of TGF-β into the vitreous body of rats causes a loss of lens transparency, and it has been suggested that intraocular administration of TGF-β could contribute to the very rapid progression of cataracts in human patients undergoing treatment to heal macular holes ( Thompson et al , 1995 ; Hales et al , 1999 ; Robertson et al , 2007 ). Moreover, several conditions associated with an increase in the levels of active TGF-β in the lens environment (e.g., diabetes, glaucoma, atypical retinoblastoma) have been linked to higher rates of cataract formation in humans ( Harding et al , 1993 ; Klein et al , 1998 ; Ochiai and Ochiai, 2002 ; Kase et al , 2008 ), as has a decrease in an anti-TGF-β defense system, estrogen ( Klein et al , 1994 ; Benitez del Castillo et al , 1997 ; Hales et al , 1997 ; Freeman et al , 2001 ). Because of the role of TGF-β in lens pathology and the importance of gap junctions to normal lens function, we examined if TGF-β affects lens cell GJIC in either the absence or presence of physiologically relevant concentrations of FGF.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Lens Gap Junctions by Transforming Growth Factor Beta

Boswell

VanSlyke

Musil

2010

MBoC

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Section: Introductionmentioning

confidence: 99%

Regulation of Lens Gap Junctions by Transforming Growth Factor Beta

Boswell

VanSlyke

Musil

2010

MBoC

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“…Although very rare (incidence less than 1%), the formation of cataracts in eyes affected by retinoblastoma has been well-documented. Radiation therapy is believed to be the major cause of retinoblastoma-related cataracts, but cataracts occur even in patients without a previous history of radiotherapy [ 4 ]. There have been a few reports on the prevalence of radiation-induced cataracts in eyes with retinoblastoma and the outcomes of cataract surgery after tumor regression [ 5 6 7 8 9 ].…”

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confidence: 99%

Outcomes of Cataract Surgery Following Treatment for Retinoblastoma

Kim

Lee

Kim

et al. 2017

Korean J Ophthalmol

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PurposeTo evaluate the long-term visual outcomes and complications of cataract surgery in eyes previously treated for retinoblastoma.MethodsWe reviewed the medical records of patients who underwent cataract extraction and intraocular lens implantation at Seoul National University Children's Hospital for a secondary cataract that developed after retinoblastoma treatment.ResultsDuring the period between 1990 and 2014, 208 eyes of 147 patients received eye-salvaging treatment (radiotherapy, chemotherapy, and local therapy) for retinoblastoma at Seoul National University Children's Hospital. Among these eyes, a secondary cataract was detected in 17 eyes of 14 patients, and five eyes of five patients underwent cataract surgery. The median age of cataract formation was 97 months (range, 38 to 153 months). The medial interval between the diagnosis of retinoblastoma and cataract formation was 79 months (range, 29 to 140 months). All patients received posterior chamber intraocular lens insertion after irrigation and aspiration of the lens through a scleral tunnel incision. Anterior vitrectomy and posterior capsulotomy were performed in two eyes and a laser capsulotomy was subsequently performed in one eye. No intraoperative and postoperative complications occurred. The median follow-up after surgery was 36 months (range, 14 to 47 months). The final best corrected visual acuities were improved in all five eyes. No intraocular tumor recurrences or metastases occurred.ConclusionsAfter retinoblastoma regression, cataract extraction in our series was not associated with tumor recurrence or metastasis. Visual improvement was noted in every patient.

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“…Hales et al 17 demonstrate that an intravitreal TGF-b injection induced posterior and anterior subcapsular cataractous changes in vivo. Kase et al 18 demonstrate that TGF-b was upregulated in tumor tissue in retinoblastoma cases with cataract. They suggest TGF-b produced by retinoblastoma cells may induce cataract formation.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical observation of anterior subcapsular cataract in eye with spontaneously regressed retinoblastoma

Shirai¹,

Okada²,

Saika³

2010

Journal of Cataract and Refractive Surgery

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We report the histological findings of secondary cataract in an eye with a spontaneously regressed retinoblastoma to obtain keys to clarify the mechanism of this phenomenon. During phacoemulsification, opacified anterior capsule was obtained, fixed in formalin, and embedded in paraffin. Paraffin sections of the specimen were histologically observed. Hematoxylin-eosin staining showed extracellular matrix accumulation in the extracted fibrous anterior subcapsular opacification. Immunohistochemistry revealed the presence of fibrous collagen types and cellular fibronectin. Presumed lens cells amid matrix were positively labeled for vimentin, alpha-smooth muscle actin, and phospho-Smad2. Histology of the fibrous anterior subcapsular opacification tissue showed the possibility of epithelial-mesenchymal transition of the lens epithelial cells in the secondary cataract following a spontaneously regressed retinoblastoma.

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Transforming Growth Factor β in Retinoblastoma-Related Cataract

Cited by 12 publications

References 9 publications

Regulation of Lens Gap Junctions by Transforming Growth Factor Beta

Regulation of Lens Gap Junctions by Transforming Growth Factor Beta

Outcomes of Cataract Surgery Following Treatment for Retinoblastoma

Immunohistochemical observation of anterior subcapsular cataract in eye with spontaneously regressed retinoblastoma

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