2018
DOI: 10.18632/aging.101615
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Abstract: Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer’s disease (AD). However, the role of Tf in AD remains unknown. Using mouse-derived neurons and APP/PS1 transgenic (Tg) mice as model systems, we firstly revealed the mechanisms of APH-1α/1β and presenilin 1 (PS1) upregulation by Fe in prostaglandin (PG) E2- and PGD2-dependent mechanisms. Specifically, Fe stimula… Show more

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Cited by 16 publications
(15 citation statements)
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References 88 publications
(115 reference statements)
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“…Increasing dopamine signalling, for example, by methylphenidate, is the first-line stimulant treatment for attention deficit/hyperactivity disorder [55]. It is interesting to note that in the study patients, the negative correlations of transferrin with attention capacity deficits seem to be in contrast to the role played by transferrin in mediating the effect of iron on the production and the deposition of Aβ, thus contributing to the pathogenesis of AD [56].…”
Section: Neurocognitive Tests and Patients' General Characteristicsmentioning
confidence: 88%
“…Different from PGE 2 and PGI 2 , PGD 2 can inhibit the activity of APH-1α/1β and PS1 (11). In this process, DP receptor mediates the action of PGD 2 (11).…”
Section: Introductionmentioning
confidence: 99%
“…Different from PGE 2 and PGI 2 , PGD 2 can inhibit the activity of APH-1α/1β and PS1 (11). In this process, DP receptor mediates the action of PGD 2 (11). As the self dehydrating product of PGD 2 , 15-deoxy-Δ 12,14 -PGJ 2 (15d-PGJ 2 ) also showed inhibition on the activity of APH-1α/1β and PS1 (11).…”
Section: Introductionmentioning
confidence: 99%
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“…1,[8][9][10] The dysfunction of TF sialylation levels may affect the iron homeostasis of brain 1,9 and thus alter the surrounding brain environments that are tightly linked to AD dementia and progression. 11 Amongst the frequently sialylated glycoproteins, carrier proteins including serum TF 12 have attracted great interest due to their central roles in transporting iron and significant regulatory roles that potentially act as supplementary diagnostic glycoproteins in multiple diseases. Clearly, more definitive and experimental information would be beneficial for better understanding of the relationship between altered sialylation of TF and iron homeostasis during AD development.…”
Section: Introductionmentioning
confidence: 99%